Department of Pathology, University of Iowa, Carver College of Medicine, Iowa City, IA 52246, USA; Medical Scientist Training Program, University of Iowa, Carver College of Medicine, Iowa City, IA 52246, USA; Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52246, USA.
Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52246, USA; Department of Microbiology and Immunology, University of Iowa, Carver College of Medicine, Iowa City, IA 52246, USA.
Cell Rep. 2021 Nov 2;37(5):109956. doi: 10.1016/j.celrep.2021.109956.
Circulating memory CD8 T cell trafficking and protective capacity during liver-stage malaria infection remains undefined. We find that effector memory CD8 T cells (Tem) infiltrate the liver within 6 hours after malarial or bacterial infections and mediate pathogen clearance. Tem recruitment coincides with rapid transcriptional upregulation of inflammatory genes in Plasmodium-infected livers. Recruitment requires CD8 T cell-intrinsic LFA-1 expression and the presence of liver phagocytes. Rapid Tem liver infiltration is distinct from recruitment to other non-lymphoid tissues in that it occurs both in the absence of liver tissue resident memory "sensing-and-alarm" function and ∼42 hours earlier than in lung infection by influenza virus. These data demonstrate relevance for Tem in protection against malaria and provide generalizable mechanistic insights germane to control of liver infections.
循环记忆性 CD8 T 细胞在肝期疟原虫感染期间的迁移和保护能力尚未确定。我们发现，效应记忆性 CD8 T 细胞（Tem）在疟原虫或细菌感染后 6 小时内浸润肝脏，并介导病原体清除。Tem 的募集与感染肝脏中炎症基因的快速转录上调相吻合。募集需要 CD8 T 细胞内在的 LFA-1 表达和肝吞噬细胞的存在。Tem 快速浸润肝脏与向其他非淋巴组织的募集明显不同，因为它既发生在没有肝脏组织驻留记忆“感知和警报”功能的情况下，也比流感病毒感染肺部早约 42 小时。这些数据表明 Tem 在预防疟疾方面的相关性，并为控制肝脏感染提供了普遍适用的机制见解。
