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糖尿病诱导的骨骼肌纤维化：起作用的纤维脂肪前体细胞。

Diabetes-induced skeletal muscle fibrosis: Fibro-adipogenic precursors at work.

机构信息

Institut NeuroMyoGène, UMR CNRS 5310 - Inserm U1217, Université Claude Bernard Lyon 1, Université Lyon, Lyon, France.

Institut NeuroMyoGène, UMR CNRS 5310 - Inserm U1217, Université Claude Bernard Lyon 1, Université Lyon, Lyon, France.

出版信息

Cell Metab. 2021 Nov 2;33(11):2095-2096. doi: 10.1016/j.cmet.2021.10.009.

DOI:10.1016/j.cmet.2021.10.009
PMID:34731650
Abstract

Skeletal muscle fibrosis is a complication of diabetes and insulin resistance. In this issue of Cell Metabolism, Farup et al. (2021) characterized fibro-adipogenic precursors (FAPs) in human skeletal muscle and showed that a CD34CD90 FAP subset is involved in diabetes-induced muscle fibrosis through PDGFRα signaling and activation of glycolysis.

摘要

骨骼肌纤维化是糖尿病和胰岛素抵抗的并发症。在本期《细胞代谢》中，Farup 等人（2021 年）描述了人类骨骼肌中的纤维脂肪前体细胞（FAPs），并表明 CD34CD90 FAP 亚群通过 PDGFRα 信号和糖酵解的激活参与了糖尿病诱导的肌肉纤维化。

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