高强度聚焦超声消融术作为化疗耐药或复发的妊娠滋养细胞肿瘤辅助手术挽救治疗的应用：两例病例报告。
High-intensity focused ultrasound ablation as an adjuvant surgical salvage procedure in gestational trophoblastic neoplasia chemotherapy with chemoresistance or recurrence: two case reports.
机构信息
Department of Laboratory Medicine, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi City, China.
Department of Gynecology and Obstetrics, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi City, China.
出版信息
Int J Hyperthermia. 2021;38(1):1584-1589. doi: 10.1080/02656736.2021.1998659.
BACKGROUND
Chemotherapy is the main treatment strategy for gestational trophoblastic neoplasia (GTN). Surgical resection is crucial to deal with chemoresistance and recurrence following chemotherapy. The aim of this study was to explore if high-intensity focused ultrasound (HIFU) can be used as a complementary technique to surgical procedures in the management of GTN.
CASE REPORT
This case report described two females who previously developed chemoresistance or recurrence during chemotherapy and then underwent HIFU as an adjuvant surgical salvage procedure. For high-risk GTN patients with chemoresistance, HIFU treatment decreased the risk of chemoresistance and shortened the course of chemotherapy. It also reduced the dosage of chemotherapeutic agents used for the patient who suffered a recurrence.
CONCLUSION
For patients with GTN who desire to preserve their uterus, HIFU may be used as a complementary technique to surgical resection in the management of GTN.
背景
化疗是妊娠滋养细胞肿瘤（GTN）的主要治疗策略。手术切除对于化疗耐药和化疗后复发至关重要。本研究旨在探讨高强度聚焦超声（HIFU）是否可作为手术的辅助技术用于 GTN 的治疗。
病例报告
本病例报告描述了 2 名女性患者，她们在化疗过程中发生化疗耐药或复发，然后接受 HIFU 作为辅助性手术挽救治疗。对于化疗耐药的高危 GTN 患者，HIFU 治疗降低了化疗耐药的风险，缩短了化疗疗程。它还减少了复发患者所用化疗药物的剂量。
结论
对于希望保留子宫的 GTN 患者，HIFU 可作为手术切除的辅助技术用于 GTN 的治疗。
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