通过去对称化构建具有顺式 1,2-二醇部分的稠合碳环的立体选择性合成：SmI 介导的内消旋环状 1,3-二酮的频哪醇偶联。
A Stereoselective Synthesis of Fused Carbocycles with a cis-1,2-Diol Moiety by Desymmetrization: SmI-Mediated Pinacol Coupling of meso-Cyclic 1,3-Diones.
机构信息
Graduate School of Biomedical Sciences, Nagasaki University.
出版信息
Chem Pharm Bull (Tokyo). 2022 Jan 1;70(1):89-93. doi: 10.1248/cpb.c21-00837. Epub 2021 Nov 2.
PMID:34732589
Abstract
Samarium diiodide (SmI)-mediated desymmetrization of a meso-cyclic 1,3-dione pinacol coupling is described. The reaction proceeds with high stereoselectivity to provide fused carbocyclic compounds with three contiguous stereogenic centers featuring an all-carbon quaternary center and a cis-1,2-diol moiety.
摘要
描述了钐二碘化（SmI）介导的介环状 1,3-二酮频哪醇偶联的去对称化。该反应具有高立体选择性，提供了具有三个连续立体中心的稠合碳环化合物，具有全碳季碳原子和顺式 1,2-二醇部分。
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