Controls Angiogenesis by Targeting VE-PTP Through Interaction With Nucleolin.

Precise regulation of angiogenesis is required for organ development, wound repair, and tumor progression. Here, we identified a novel gene, (New XingHuo light), that is conserved in vertebrates and that plays a crucial role in vascular integrity and angiogenesis. Bioinformatic analysis uncovered its essential roles in development based on co-expression with several key developmental genes. Knockdown of in zebrafish causes global and pericardial edema, loss of blood circulation, and vascular defects characterized by both reduced vascularization in intersegmental vessels and decreased sprouting in the caudal vein plexus. The gene also affects human endothelial cell behavior . We found that functions in part by targeting VE-PTP through interaction with NCL (nucleolin). Loss of (a VE-PTP ortholo) in zebrafish resulted in defects similar to knockdown. Moreover, deficiency attenuates tumor invasion and proteins (including VE-PTP and NCL) associated with angiogenesis and EMT. These findings illustrate that can regulate angiogenesis via a novel -NCL-VE-PTP axis, providing a new therapeutic target for modulating vascular formation and function, especially for cancer treatment.