Kazimierz Pulaski University of Technology and Humanities Radom, Faculty of Medical Sciences and Health Sciences, Radom, Poland.
Department of Neurosurgery, Postgraduate Medical Centre, Warsaw, Poland.
Biomed Res Int. 2021 Oct 25;2021:2398488. doi: 10.1155/2021/2398488. eCollection 2021.
The high frequency of traumatic brain injury imposes severe economic stress on health and insurance services. The objective of this study was to analyze the association between the serum S100B protein, the Gosling pulsatility index (PI), and the level of oxygen saturation at the tip of the internal jugular vein (SjVO2%) in patients diagnosed with severe TBI. The severity of TBI was assessed by a GCS score ≤ 8 stratified by Glasgow outcome scale (GOS) measured on the day of discharge from the hospital. Two groups were included: GOS < 4 (unfavorable group (UG)) and GOS ≥ 4 (favorable group (UG)). S100B levels were higher in the UG than in the FG. PI levels in the UG were also substantially higher than in the FG. There were similar levels of SjVO2 in the two groups. This study confirmed that serum S100B levels were higher in patients with unfavorable outcomes than in those with favorable outcomes. Moreover, a clear demarcation in PI between unfavorable and FGs was observed. This report shows that mortality and morbidity rates in patients with traumatic brain injury can be assessed within the first 4 days of hospitalization using the S100B protein, PI values, and SjVO2.
颅脑创伤的高发病率给卫生和保险服务带来了严重的经济压力。本研究的目的是分析血清 S100B 蛋白、Gosling 搏动指数（PI）和颈内静脉终末血氧饱和度（SjVO2%）与诊断为严重颅脑创伤患者之间的关系。采用格拉斯哥昏迷评分（GCS）≤8 分层，根据出院当天的格拉斯哥结果量表（GOS）评估 TBI 的严重程度。纳入两组：GOS<4（预后不良组（UG））和 GOS≥4（预后良好组（FG））。UG 组的 S100B 水平高于 FG 组。UG 组的 PI 水平也明显高于 FG 组。两组的 SjVO2 水平相似。本研究证实，预后不良组患者的血清 S100B 水平高于预后良好组患者。此外，在不良和 FG 之间观察到 PI 的明显分界。本报告表明，使用 S100B 蛋白、PI 值和 SjVO2 可以在住院后的头 4 天内评估颅脑创伤患者的死亡率和发病率。
