Department of Urology, University of California San Diego, La Jolla, California, USA.
Population Science, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.
Andrologia. 2022 Feb;54(1):e14293. doi: 10.1111/and.14293. Epub 2021 Nov 3.
We determine the time to first live birth for female partners of males after a cancer diagnosis. Our group performed a retrospective, population-based, age-matched cohort study of Utah male residents diagnosed with cancer at age 18 years or later between 1956 and 2013 (exposed) matched to male Utah residents without cancer diagnosis (unexposed). Using stratified Cox proportional hazard models, we adjusted for race, ethnicity and number of live births prior to cancer diagnosis, to estimate the effect of time to a partner live birth following cancer diagnosis. Our study cohort included 19,303 men diagnosed with cancer (exposed) and 93,608 age-matched men without cancer diagnoses (unexposed). Exposed men were less likely to have a live birth prior to first cancer diagnosis (60.7% vs. 65.4%, p < 0.001) and after first cancer diagnosis (10.9% vs. 12.2%, p < 0.001) compared to unexposed men. Exposed men had a fertility hazard rate that was 31% lower after cancer diagnosis date than unexposed men (HR: 0.69; 95% CI: 0.65-0.72). This was most profound for men aged 18-30 years (HR: 0.59, 95% CI: 0.55-0.63). Male cancer survivors have a 31% lower female partner live birth rate after cancer diagnosis. These findings are important for patient counselling regarding fertility preservation at the time of cancer diagnosis.
我们确定了男性癌症诊断后其女性伴侣的首次活产时间。我们的团队进行了一项回顾性、基于人群、年龄匹配的队列研究，研究对象为 1956 年至 2013 年间年龄在 18 岁及以上被诊断患有癌症的犹他州男性居民（暴露组），并与未被诊断患有癌症的犹他州男性居民（非暴露组）进行匹配。我们使用分层 Cox 比例风险模型，调整了种族、民族和癌症诊断前的活产数量，以估计癌症诊断后伴侣活产时间的影响。我们的研究队列包括 19303 名被诊断患有癌症的男性（暴露组）和 93608 名年龄匹配的未被诊断患有癌症的男性（非暴露组）。与非暴露组相比，暴露组男性在首次癌症诊断前（60.7% vs. 65.4%，p<0.001）和首次癌症诊断后（10.9% vs. 12.2%，p<0.001）的活产可能性更低。与非暴露组相比，暴露组男性在癌症诊断日期后生育风险率降低了 31%（HR：0.69；95%CI：0.65-0.72）。这在 18-30 岁的男性中最为明显（HR：0.59，95%CI：0.55-0.63）。男性癌症幸存者在癌症诊断后其女性伴侣的活产率降低了 31%。这些发现对于癌症诊断时有关生育力保护的患者咨询很重要。
