Surgery Department, Unidade Local de Saúde de Matosinhos.
Surgery Department, Centro Hospitalar Universitário de São João, Porto, Portugal.
Future Oncol. 2021 Dec;17(35):4947-4957. doi: 10.2217/fon-2021-0707. Epub 2021 Nov 4.
To investigate the value of previously described pretreatment hematological and biochemical biomarkers as predictors of pathological response. The authors performed a retrospective analysis of 191 patients with locally advanced rectal cancer who underwent long-course neoadjuvant chemoradiotherapy at two Portuguese centers. The authors performed logistic regression analysis to search for predictive markers of pathological complete and good response. High platelet-neutrophil index (p = 0.042) and clinical tumor stage >2 (p = 0.015) were predictive of poor response. None of the analyzed biomarkers predicted pathological complete response in this study. A high platelet-neutrophil index before neoadjuvant chemoradiotherapy could help predict poorer pathological response in patients with locally advanced rectal cancer. However, no other blood biomarker predicted incomplete or poor response in this study.
为了探究预处理血液学和生化标志物作为预测病理反应的价值。作者对在葡萄牙的两个中心接受长程新辅助放化疗的 191 例局部晚期直肠癌患者进行了回顾性分析。作者进行了逻辑回归分析，以寻找病理完全缓解和良好反应的预测标志物。高血小板-中性粒细胞指数（p=0.042）和临床肿瘤分期>2（p=0.015）是反应不良的预测因素。在本研究中，没有分析的生物标志物预测病理完全缓解。新辅助放化疗前高血小板-中性粒细胞指数可能有助于预测局部晚期直肠癌患者的病理反应较差。然而，在本研究中，没有其他血液生物标志物预测不完全或不良反应。
