modulates trophoblast cell proliferation and migration through .

Preeclampsia is a severe pregnancy complication characterized by hypertension and may cause maternal morbidity and mortality. A better understanding of the essential genes involved in preeclampsia pathophysiology is urgently needed. This study investigated the function and molecular mechanisms of pumilio RNA binding family member 1 () in extravillous trophoblast cells (EVTs). The interaction between protein and mRNA was verified by RNA pull-down assays, RNA immunoprecipitation assays, and luciferase reporter assays. The mRNA and protein levels of the genes involved were determined by RT-qPCR and western blot assays, respectively. Our results demonstrated that could bind to the 3'-untranslated region of low-density lipoprotein receptor-related protein 6 () mRNA, resulting in reduced expression of mRNA and protein. Repression of resulted in enhanced colony formation, cell proliferation, migration, and invasion of EVTs. The -depletion-mediated promotion effects on EVTs could be abrogated by knockdown. regulates the growth and mobility of EVTs by modulating expression. Developing strategies to balance and levels may be beneficial for the management of preeclampsia patients.