Globo H 和 SSEA-4 在癌症发展和进展中的作用及其作为治疗靶点的潜力。
The role of Globo H and SSEA-4 in the development and progression of cancer, and their potential as therapeutic targets.
机构信息
Director, GI Oncology, Scripps Clinic & Scripps MD Anderson Cancer Center, 10710 N Torrey Pines Road, La Jolla, CA 92037, USA.
Scripps Clinic & Scripps MD Anderson Cancer Center, 10710 N Torrey Pines Road, LA Jolla, CA 92037, USA.
出版信息
Future Oncol. 2022 Jan;18(1):117-134. doi: 10.2217/fon-2021-1110. Epub 2021 Nov 4.
Glycans, chains of sugar molecules found conjugated to cell proteins and lipids, contribute to their growth, movement and differentiation. Aberrant glycosylation is a hallmark of several medical conditions including tumorigenesis. Glycosphingolipids (GSLs), consisting of glycans conjugated to a lipid (ceramide) core, are found in the lipid bilayer of eukaryotic cell membranes. GSLs, play an active role in cell processes. Several GSLs are expressed by human embryonic stem cells and have been found to be overexpressed in several types of cancer. In this review, we discuss the data, hypotheses and perspectives related to the GSLs Globo H and SSEA-4.
糖链，即与细胞蛋白和脂质结合的糖分子链，有助于它们的生长、运动和分化。糖基化异常是包括肿瘤发生在内的几种医学病症的特征。糖鞘脂（GSL）由与脂质（神经酰胺）核心结合的糖组成，存在于真核细胞膜的脂双层中。GSL 在细胞过程中发挥着积极的作用。几种 GSL 由人胚胎干细胞表达，并且已经在几种类型的癌症中发现过度表达。在这篇综述中，我们讨论了与 Gb3（Globo H）和 SSEA-4 相关的数据、假说和观点。
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