Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Department of Gynecology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Semin Immunopathol. 2024 Oct 21;46(6):16. doi: 10.1007/s00281-024-01025-6.
Ovarian cancer remains a formidable challenge in oncology due to its late-stage diagnosis and limited treatment options. Recent research has revealed the intricate interplay between glycan diversity and the immune microenvironment within ovarian tumors, shedding new light on potential therapeutic strategies. This review seeks to investigate the complex role of glycans in ovarian cancer and their impact on the immune response. Glycans, complex sugar molecules decorating cell surfaces and secreted proteins, have emerged as key regulators of immune surveillance in ovarian cancer. Aberrant glycosylation patterns can promote immune evasion by shielding tumor cells from immune recognition, enabling disease progression. Conversely, certain glycan structures can modulate the immune response, leading to either antitumor immunity or immune tolerance. Understanding the intricate relationship between glycan diversity and immune interactions in ovarian cancer holds promise for the development of innovative therapeutic approaches. Immunotherapies that target glycan-mediated immune evasion, such as glycan-based vaccines or checkpoint inhibitors, are under investigation. Additionally, glycan profiling may serve as a diagnostic tool for patient stratification and treatment selection. This review underscores the emerging importance of glycan diversity in ovarian cancer, emphasizing the potential for unraveling immune interplay and advancing tailored therapeutic prospects for this devastating disease.
卵巢癌仍然是肿瘤学中的一个巨大挑战，因为其诊断晚期和治疗选择有限。最近的研究揭示了糖缀合物多样性与卵巢肿瘤内免疫微环境之间的复杂相互作用，为潜在的治疗策略提供了新的线索。这篇综述旨在探讨糖缀合物在卵巢癌中的复杂作用及其对免疫反应的影响。糖缀合物是在细胞表面和分泌蛋白上装饰的复杂糖分子，已成为卵巢癌中免疫监视的关键调节剂。异常的糖基化模式可以通过屏蔽肿瘤细胞免受免疫识别来促进免疫逃逸，从而促进疾病进展。相反，某些糖缀合物结构可以调节免疫反应，导致抗肿瘤免疫或免疫耐受。了解糖缀合物多样性与卵巢癌中免疫相互作用之间的复杂关系有望为开发创新的治疗方法提供帮助。靶向糖基化介导的免疫逃逸的免疫疗法，如基于糖的疫苗或检查点抑制剂，正在研究中。此外，糖谱分析可以作为患者分层和治疗选择的诊断工具。这篇综述强调了糖缀合物多样性在卵巢癌中的新兴重要性，强调了揭示免疫相互作用和推进针对这种毁灭性疾病的个体化治疗前景的潜力。
