Czech Institute of Informatics, Robotics and Cybernetics, Czech Technical University in Prague, Prague, Czech Republic.
MWCare Ltd., Prague, Czech Republic.
Stud Health Technol Inform. 2021 Oct 27;285:49-57. doi: 10.3233/SHTI210572.
The paper describes some aspects of precision medicine and shows the importance of pharmacokinetics and pharmacodynamics for the therapeutic drug monitoring and model-informed precision dosing. A key element in the design of the pharmacokinetics and pharmacodynamics (PKPD) models is relevant literature search that represents an essential step in the procurement and validation of a new drug. Available search engine resources do not offer specific functionalities that are required for efficient and relevant search in reliable literature sources. We present a prototype of such an intelligent search engine and show its results on real project data.
本文描述了精准医学的一些方面,并展示了药代动力学和药效动力学对于治疗药物监测和模型指导的精准给药的重要性。设计药代动力学和药效动力学(PKPD)模型的一个关键要素是相关文献检索,这是获取和验证新药的一个重要步骤。现有的搜索引擎资源并未提供高效且相关的搜索所需的特定功能,也无法确保搜索结果来自可靠的文献来源。我们展示了这样一个智能搜索引擎的原型,并展示了其在实际项目数据上的结果。