铱(III)催化的电化学氧化分子内脱氢 C-H/N-H 偶联反应合成 N-H 吲哚。
Ir(III)-Catalysed electrooxidative intramolecular dehydrogenative C-H/N-H coupling for the synthesis of N-H indoles.
机构信息
Center for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science (IBS), Daejeon 34141, South Korea.
Department of Chemistry, Korea Advanced Institute of Science & Technology (KAIST), Daejeon 34141, South Korea.
出版信息
Chem Commun (Camb). 2021 Nov 19;57(92):12309-12312. doi: 10.1039/d1cc05882g.
Herein, an iridium(III)-catalysed electrooxidative intramolecular dehydrogenative C-H/N-H coupling of unprotected 2-alkenyl anilines is described. The developed method allows the synthesis of a variety of 3-substituted N-H indole scaffolds under undivided electrolytic conditions. Mechanistic studies suggest that the reaction proceeds through the electro-oxidation induced reductive elimination pathway.
本文描述了一种铱(III)催化的未保护 2-烯基苯胺的电氧化分子内脱氢 C-H/N-H 偶联反应。所开发的方法允许在不分流电解条件下合成各种 3-取代的 N-H 吲哚骨架。机理研究表明，反应通过电氧化诱导的还原消除途径进行。
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