糖基化肽聚糖骨架片段的自动组装。
Automated glycan assembly of peptidoglycan backbone fragments.
机构信息
Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Muehlenberg 1, 14476 Potsdam, Germany.
University of Pavia, Department of Organic Chemistry, V.le Torquato Taramelli, 10, 27100 Pavia, Italy.
出版信息
Org Biomol Chem. 2021 Nov 25;19(45):9829-9832. doi: 10.1039/d1ob01987b.
We report the automated glycan assembly (AGA) of different oligosaccharide fragments of the bacterial peptidoglycan (PGN) backbone. Iterative addition on a solid support of an acetyl glucosamine and a new muramic acid building block is followed by cleavage from the solid support and final deprotection providing 10 oligosaccharides up to six units.
我们报告了细菌肽聚糖（PGN）骨架的不同寡糖片段的自动糖基化组装（AGA）。在固体支持物上重复添加乙酰葡萄糖胺和新的 muramic 酸砌块，然后从固体支持物上裂解，最后进行脱保护，提供多达六个单位的 10 个寡糖。
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