消炎痛在猫肠系膜血管床中血管收缩活性的特性研究

Characterization of the vasoconstrictor activity of indomethacin in the mesenteric vascular bed of the cat.

作者信息

Lippton H L, Armstead W M, Hyman A L, Kadowitz P J

出版信息

Prostaglandins Leukot Med. 1987 Apr;27(1):81-91. doi: 10.1016/0262-1746(87)90061-8.

Abstract

The effects of indomethacin on vascular resistance were investigated in the feline mesenteric vascular bed under conditions of constant blood flow. Indomethacin produced mesenteric vasoconstriction that was dose-dependent but was less active than U46619, the thromboxane mimic, angiotensin II, PGF2 alpha and norepinephrine. The vasoconstrictor response to indomethacin was not altered by meclofenamate and phenoxybenzamine. Indomethacin, in a dose that blocked the systemic vasodepressor response to arachidonic acid, did not alter mesenteric vasoconstrictor responses to sympathetic nerve stimulation, norepinephrine, angiotensin II, U46619, and U44069. The present data suggest that in the feline intestinal vascular bed indomethacin has marked vasoconstrictor activity that occurs independent of activation of alpha-adrenoceptors and formation of cyclooxygenase products possessing pressor activity. The present data suggest that cyclooxygenase products do not modulate vasoconstrictor responses as well as the sympathetic nervous system in the intestinal vascular bed of the cat.

摘要

在血流恒定的条件下，研究了吲哚美辛对猫肠系膜血管床血管阻力的影响。吲哚美辛可引起肠系膜血管收缩，且呈剂量依赖性，但活性低于血栓素类似物U46619、血管紧张素II、前列腺素F2α和去甲肾上腺素。甲氯芬那酸和酚苄明不会改变吲哚美辛引起的血管收缩反应。吲哚美辛在阻断对花生四烯酸的全身血管减压反应的剂量下，不会改变肠系膜血管对交感神经刺激、去甲肾上腺素、血管紧张素II、U46619和U44069的收缩反应。目前的数据表明，在猫的肠血管床中，吲哚美辛具有明显的血管收缩活性，其发生独立于α-肾上腺素能受体的激活以及具有升压活性的环氧化酶产物的形成。目前的数据表明，在猫的肠血管床中，环氧化酶产物对血管收缩反应的调节作用不如交感神经系统。