Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
DNA Cell Biol. 2021 Nov;40(11):1381-1395. doi: 10.1089/dna.2020.6384. Epub 2021 Nov 3.
Gliomas are common intracranial tumors with high morbidity and mortality in adults. Transmembrane protein 2 (TMEM2) is involved in the malignant behavior of solid tumors. TMEM2 regulates cell adhesion and metastasis as well as intercellular communication by degrading nonprotein components of the extracellular matrix. This study aimed to evaluate the relationship between expression levels and glioma subtypes or patient prognosis. Our findings revealed that expression was abnormally upregulated in high-grade glioma. Moreover, combining , the status of isocitrate dehydrogenase () and 1p19q, we subdivided molecular subtypes with significant differences in survival. Patients in the MT-codel-low subgroup had better prognosis than those in the WT-no-codel-high subgroup, who fared the worst. Additionally, correlation analysis of and immune cell infiltration indicated an altered tumor microenvironment (TME) and cell redistribution in the high-expression subtype. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that focal adhesion and PI3K-Akt signaling pathways were enriched in the -expressing group. In conclusion, aberrant expression can be used as an independent prognostic marker for refining glioma molecular subtyping and accurate prognosis. These findings will improve rational decision making to provide individualized therapy for patients with glioma.
神经胶质瘤是成人中常见的颅内肿瘤，发病率和死亡率都很高。跨膜蛋白 2（TMEM2）参与实体瘤的恶性行为。TMEM2 通过降解细胞外基质的非蛋白成分来调节细胞黏附和转移以及细胞间通讯。本研究旨在评估表达水平与神经胶质瘤亚型或患者预后之间的关系。我们的研究结果表明，在高级别神经胶质瘤中，表达水平异常上调。此外，结合 、异柠檬酸脱氢酶（IDH）和 1p19q 的状态，我们对具有显著生存差异的分子亚型进行了细分。MT-codel-low 亚组的患者预后优于 WT-no-codel-high 亚组，后者的预后最差。此外，和免疫细胞浸润的相关性分析表明，在高表达亚型中，肿瘤微环境（TME）发生改变，细胞重新分布。基因本体论（GO）和京都基因与基因组百科全书（KEGG）分析表明，粘着斑和 PI3K-Akt 信号通路在表达组中富集。总之，异常的 表达可作为一种独立的预后标志物，用于完善神经胶质瘤的分子亚型和准确预后。这些发现将有助于做出合理的决策，为神经胶质瘤患者提供个体化治疗。
