Dr. Stierstorfer is from Hurley Dermatology, PC, West Chester, Pennsylvania; the Perelman School of Medicine at the University of Pennsylvania, Philadelphia; IBS Centers for Advanced Food Allergy Testing, LLC, North Wales, Pennsylvania; and IBS-80, LLC, Philadelphia. Dr. Toro is from the Department of Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia.
Cutis. 2021 Aug;108(2):91-95. doi: 10.12788/cutis.0321.
This study investigated the utility of skin patch testing to identify delayed-type food hypersensitivities that trigger irritable bowel syndrome (IBS) symptoms. Using an extensive panel of type IV food allergens, patch testing was performed on individuals with IBS symptoms, after which patch test-directed avoidance diets were implemented in those patients with patch test reactions. All patients placed on avoidance diets were invited to participate in a questionnaire-based study assessing IBS symptom response to the diet. Primary end points included average abdominal pain during the more than 3-month food avoidance period and degree of improvement in overall IBS symptoms 3 or more months after initiation of the avoidance period. The results from this study add to the expanding body of evidence of a role for delayed-type food hypersensitivities in the pathogenesis of some cases of IBS. Skin patch testing to type IV food allergens offers a new approach to evaluating and managing these patients.
本研究探讨了皮肤贴片试验在识别引发肠易激综合征 (IBS) 症状的迟发型食物过敏中的效用。使用广泛的 IV 型食物过敏原面板，对有 IBS 症状的个体进行了贴片试验，然后对有贴片试验反应的患者实施了贴片试验指导的回避饮食。所有被要求回避饮食的患者都被邀请参加一项基于问卷调查的研究，评估饮食对 IBS 症状的反应。主要终点包括在超过 3 个月的食物回避期间的平均腹痛和在回避期开始后 3 个月以上的整体 IBS 症状改善程度。这项研究的结果增加了迟发型食物过敏在某些 IBS 病例发病机制中的作用的不断扩大的证据。IV 型食物过敏原的皮肤贴片试验为评估和管理这些患者提供了一种新方法。
