可降解聚乳酸-Mg-Ca(PO)_4 三相复合材料的力学性能及生物医学应用特性。

Mechanical properties and biomedical application characteristics of degradable polylactic acid-Mg-Ca(PO) three-phase composite.

机构信息

Department of Mechanical Engineering, Southern Taiwan University of Science and Technology, Tainan, 710, Taiwan.

Department of Materials Science and Engineering, National Cheng Kung University, Tainan, 701, Taiwan.

出版信息

J Mech Behav Biomed Mater. 2022 Jan;125:104949. doi: 10.1016/j.jmbbm.2021.104949. Epub 2021 Oct 29.

DOI:10.1016/j.jmbbm.2021.104949

PMID:34736029

Abstract

Polylactic acid (PLA), pure magnesium powder, and calcium phosphate powder were used to form a three-phase degradable biomedical composite. The effects of various powder proportions in polylactic acid-Mg-Ca(PO) composites were analyzed through mechanical and biological tests, which revealed that both the tensile and impact strength of the composite increased. Additionally, ductility presented only after a small proportion of powder was added. Hardness slightly increased because of dispersion strengthening. Furthermore, the addition of pure magnesium and calcium phosphate accelerated the degradation rate, and biocompatible salts were generated after degradation, which can improve healing and renewal in bone tissue. None of the composites exhibited cytotoxicity, meeting biological safety requirements. Overall, PLA10M10C (10 wt.% Mg, 10 wt.% Ca(PO)) exhibited superior performance. Accordingly, PLA10M10C can serve as a reference for degradable biomedical material applications in orthopedic implants.

摘要

聚乳酸（PLA）、纯镁粉和磷酸钙粉末被用来形成一种三相可降解生物医学复合材料。通过力学和生物学测试分析了聚乳酸-Mg-Ca(PO)复合材料中各种粉末比例的影响，结果表明复合材料的拉伸和冲击强度都有所提高。此外，只有加入少量粉末后才会表现出延展性。由于弥散强化，硬度略有增加。此外，纯镁和磷酸钙的加入加速了降解速度，降解后产生了生物相容性盐，可以改善骨组织的愈合和更新。这些复合材料均无细胞毒性，符合生物安全性要求。总的来说，PLA10M10C（10wt.%Mg，10wt.%Ca(PO)）表现出优异的性能。因此，PLA10M10C 可以作为骨科植入物中可降解生物医学材料应用的参考。