Katiyar Shweta, Yadav Dhananjay
Department of Biochemistry, Gajra Raja Medical College, Gwalior (M.P) 474001,India.
Department of Medical Biotechnology, Yeungnam University, Gyeongsan,South Korea.
Curr Pharm Des. 2022;28(3):225-231. doi: 10.2174/1381612827666211104154928.
Melasma is a hypermelanotic skin disorder characterized by dark brown macules of symmetrical sizes and shapes that develop over time. Apart from the multiple etiological factors for melasma, such as hormonal imbalances, thyroid dysfunction, drugs, and contraceptive pills, a new and significant cause has been discovered: the effect of oxidative stress. Oxidative stress is the result of disequilibrium between reactive oxygen species and antioxidants in the cells. It is a key element that can cause skin hypopigmentation or hyperpigmentation. The physiological significance of reactive oxygen species and its function in skin health are addressed in this study. The development process and pathophysiology of reactive oxygen species with melasma disorder are also highlighted and the advantages of integrating antioxidants in clinical and experimental environments are discussed.
黄褐斑是一种色素沉着过度的皮肤疾病，其特征为随着时间推移出现大小和形状对称的深褐色斑疹。除了黄褐斑的多种病因，如激素失衡、甲状腺功能障碍、药物和避孕药外，还发现了一个新的重要病因：氧化应激的影响。氧化应激是细胞内活性氧和抗氧化剂之间失衡的结果。它是导致皮肤色素减退或色素沉着过度的关键因素。本研究探讨了活性氧的生理意义及其在皮肤健康中的作用。还强调了活性氧与黄褐斑疾病的发展过程和病理生理学，并讨论了在临床和实验环境中整合抗氧化剂的优势。
