Division of Pediatric Gastroenterology and Nutrition, Jersey Shore University Medical Center, K. Hovnanian Children's Hospital, Hackensack Meridian Health, 19 Davis Avenue, 5th Floor, Neptune, NJ 07753, USA.
Florida State University, Center for Digestive Health and Nutrition, Arnold Palmer Hospital for Children, Orlando Health, 60 W Gore Street, Orlando, FL 32806, USA.
Pediatr Clin North Am. 2021 Dec;68(6):1205-1219. doi: 10.1016/j.pcl.2021.07.007.
Celiac disease is an autoimmune enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. In patients with suspected celiac disease, measurement of serum IgA antibodies to tissue transglutaminase-2 has a high sensitivity and specificity and is the first screening test that should be ordered. The diagnosis of celiac disease is based on the presence of mucosal damage in small intestinal biopsies in patients having circulating celiac disease-specific antibodies. Celiac disease management includes lifelong adherence to a gluten-free diet and continuous long-term follow-up.
乳糜泻是一种由遗传易感个体摄入麸质引起的自身免疫性肠病。在疑似乳糜泻患者中，血清 IgA 抗体对组织转谷氨酰胺酶-2 的测定具有较高的敏感性和特异性，是应首先进行的筛选试验。乳糜泻的诊断基于存在循环乳糜泻特异性抗体的患者的小肠活检中的粘膜损伤。乳糜泻的治疗包括终生坚持无麸质饮食和持续的长期随访。
