Institute of Food Safety and Environment Monitoring, and MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou 350108, PR China.
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China.
Adv Drug Deliv Rev. 2021 Dec;179:114032. doi: 10.1016/j.addr.2021.114032. Epub 2021 Nov 1.
Employing natural cells as drug carriers has been a hotspot in recent years, attributing to their biocompatibility and inherent dynamic properties. In the earlier stage, cells were mainly used as vehicles by virtue of their lipid-delimited compartmentalized structures and native membrane proteins. The scope emphasis was 'what cell displays' instead of 'how cell changes'. More recently, the dynamic behaviours, such as changes in surface protein patterns, morphologies, polarities and in-situ generation of therapeutics, of natural cells have drawn more attention for developing advanced drug delivery systems by fully taking advantage of these processes. In this review, we revolve around the dynamic cellular transformation behaviours which facilitate targeted therapy. Cellular deformation in geometry shape, spitting smaller vesicles, activation of antigen present cells, polarization between distinct phenotypes, local production of therapeutics, and hybridization with synthetic materials are involved. Other than focusing on the traditional delivery of concrete cargoes, more functional 'handles' that are derived from the cells themselves are introduced, such as information exchange, cellular communication and interactions between cell and extracellular environment.
利用天然细胞作为药物载体是近年来的一个热点，这归因于它们的生物相容性和固有动力学特性。在早期阶段，细胞主要通过其脂质限定的分隔结构和天然膜蛋白作为载体来使用。重点是“细胞展示什么”，而不是“细胞如何变化”。最近，天然细胞的动态行为，如表面蛋白模式、形态、极性和原位生成治疗剂的变化，引起了更多的关注，通过充分利用这些过程来开发先进的药物传递系统。在这篇综述中，我们围绕着促进靶向治疗的动态细胞转化行为展开讨论。涉及到细胞在几何形状上的变形、分裂成更小的囊泡、抗原呈递细胞的激活、不同表型之间的极化、局部产生治疗剂以及与合成材料的杂交等。除了关注传统的具体货物的传递外，还引入了更多源自细胞本身的功能性“抓手”，如信息交换、细胞通讯以及细胞与细胞外环境之间的相互作用。
