Kahnberg K E, Thilander H
Swed Dent J. 1987;11(1-2):61-70.
The effects of radiation on the healing of standardized, excisional wounds in the palate was studied in 48 white rats of the Sprague-Dawley strain. A single dose radiation of respectively 16 Gy to one group and 20 Gy to another was given three weeks before the excisional wounds were made. Healing of the wounds was followed for three weeks in the irradiated groups and also in one control group. Three rats were killed at 0, 1, 3, 5, 7, 10, 14 and 21 days from each group. The wound area was measured with a square millimeter grid on photographs taken with standardized technique and histological analysis of serial sections from the wound region performed. The results showed that the wound healing was heavily disturbed in the 20 Gy group with more or less extended bone necrosis and inflammatory reactions with a large open wound surface after three weeks, whereas in the 16 Gy group the healing was somewhat slower than the control group but not as complicated as in the 20 Gy group.
在48只斯普拉格-道利品系的白色大鼠中，研究了辐射对腭部标准化切除伤口愈合的影响。在制造切除伤口前三周，分别对一组给予16 Gy的单次剂量辐射，对另一组给予20 Gy的单次剂量辐射。对辐照组和一个对照组的伤口愈合情况进行了三周的跟踪观察。每组在第0、1、3、5、7、10、14和21天处死3只大鼠。用标准化技术拍摄的照片上的平方毫米网格测量伤口面积，并对伤口区域的连续切片进行组织学分析。结果显示，20 Gy组的伤口愈合受到严重干扰，三周后出现或多或少的广泛性骨坏死和炎症反应，伤口表面大面积开放；而16 Gy组的愈合比对照组稍慢，但不像20 Gy组那样复杂。
