Wang Zi-Yan, Li Lei, Liu Jian-Xun, Meng Hong-Xu, Miao Lan, Sun Ming-Qian, Zhang Ye-Hao
Beijing Key Laboratory of Chinese Materia Pharmacology, National Cardiouascular Disease Research Center of Tradtional Chinese Medicine, Institute of Basic Medical Sciences of Xiyuan hospital,China Academy of Chinese Medical Sciences Beijing 100091, China.
Zhongguo Zhong Yao Za Zhi. 2021 Oct;46(20):5201-5209. doi: 10.19540/j.cnki.cjcmm.20210629.701.
The traditional Chinese medicine(TCM) syndrome of blood stasis refers to blood stagnation in meridians and viscera, with the main symptoms of pain, mass, bleeding, purple tongue, and unsmooth pulse. Cardiovascular and cerebrovascular diseases are among the major chronic diseases seriously harming the health of the Chinese. Among the coronary heart disease and stroke patients, most demonstrate the blood stasis syndrome. Platelet is considered to be one of the necessary factors in thrombosis, which closely relates to the TCM syndrome of blood stasis and the occurrence of cardiovascular and cerebrovascular diseases. The clinical and laboratory research on platelet activation and aggregation has been paid more and more attention. Its purpose is to treat and prevent blood stasis syndrome. In this study, the authors analyzed the research on the dysfunctions of platelets in blood stasis syndrome, biological basis of TCM blood stasis syndrome, and the effect of blood-activating stasis-resolving prescriptions on platelets, aiming at providing a reference for exploring the mechanism of platelet intervention in the treatment of TCM blood stasis syndrome and the pathways and targets of Chinese medicine in the prevention and treatment of the syndrome.
中医血瘀证是指经络和脏腑血液瘀滞,主要症状为疼痛、肿块、出血、舌紫、脉涩。心脑血管疾病是严重危害中国人健康的主要慢性病之一。在冠心病和中风患者中,大多数表现为血瘀证。血小板被认为是血栓形成的必要因素之一,与中医血瘀证及心脑血管疾病的发生密切相关。血小板活化和聚集的临床及实验室研究越来越受到关注。其目的是治疗和预防血瘀证。在本研究中,作者分析了血瘀证中血小板功能障碍的研究、中医血瘀证的生物学基础以及活血化瘀方剂对血小板的作用,旨在为探索血小板干预治疗中医血瘀证的机制以及中医防治该证的途径和靶点提供参考。