Hammond S, Keyhani-Rofagha S, O'Toole R V
Acta Cytol. 1987 May-Jun;31(3):276-80.
Between 1979 and 1984, 678 breast fine needle aspiration (FNA) cytologic specimens were received in our laboratory; tissue follow-up was available for 159 cases (23%). The diagnoses rendered in cases with subsequent tissue study were benign (41%), insufficient (10.5%), atypical and/or suspicious for carcinoma (10.5%) and malignant (38%). Using the tissue diagnosis as the standard, there were four false-negative cytologic results and one false-positive result. Considering only cases with a definitive diagnosis of benign or malignant, the sensitivity of cytologic interpretation for diagnosing malignancy on adequate material was 94% while the specificity was 98%; the overall efficiency of the test was thus 96%. The predictive values were 98% for a positive test and 94% for a negative test. Of the total number of submitted cases, a correct and definitive diagnosis was rendered 76% of the time. Calculation of similar statistics from six other series in which the FNA cytologic diagnoses were compared with the histologic diagnoses yielded data almost identical to our findings. The high degree of uniformity in the data indicates that these statistical parameters can be used as standards for evaluating the efficiency of breast FNA cytology.
1979年至1984年间，我们实验室共收到678例乳腺细针穿刺（FNA）细胞学标本；其中159例（23%）有组织学随访结果。后续进行组织学检查的病例诊断结果为良性（41%）、标本不足（10.5%）、非典型和/或可疑癌（10.5%）以及恶性（38%）。以组织学诊断为标准，有4例假阴性细胞学结果和1例假阳性结果。仅考虑明确诊断为良性或恶性的病例，在足够标本的情况下，细胞学诊断恶性肿瘤的敏感性为94%，特异性为98%；因此该检查的总效率为96%。阳性检查的预测值为98%，阴性检查的预测值为94%。在所有送检病例中，76%的病例获得了正确明确的诊断。对其他六个将FNA细胞学诊断与组织学诊断进行比较的系列进行类似统计计算，得出的数据与我们的结果几乎相同。数据的高度一致性表明，这些统计参数可用作评估乳腺FNA细胞学检查效率的标准。
