School of Pharmacy, Lanzhou University, Lanzhou 730030, Gansu, P.R. China.
School of Physics and Astronomy, Cardiff University, Cardiff, Wales CF243AA, United Kingdom.
Mol Pharm. 2021 Dec 6;18(12):4531-4542. doi: 10.1021/acs.molpharmaceut.1c00735. Epub 2021 Nov 5.
Having benefited from the combination of different therapeutic modalities, functionalized nanoplatforms with synergistic strategies have aroused great interest in anticancer treatment. Herein, an engineered, a biodegradable hollow mesoporous organosilica nanoparticle (HMON)-based nanoplatform was fabricated for photothermal-enhanced chemotherapy of tumor. For the first time, we demonstrated that HMONs could serve as nanocarriers for co-delivering of both the paclitaxel and photothermal agent new indocyanine green (IR820), denoted as Paclitaxel/IR820@ HMONs-PEG. The as-prepared nanosystem exhibited a high paclitaxel-loading capacity of 28.4%, much higher than most paclitaxel-loaded nanoformulations. Furthermore, incorporating thioether bonds (S-S) into the HMONs' framework endowed them with GSH-responsive biodegradation behavior, leading to the controllable release of drugs under a tumor reducing microenvironment, and hindered the premature release of paclitaxel. Upon being irradiated with an NIR laser, the obtained co-delivery nanosystem exhibited great photothermal properties generated from IR820. The fabricated nanocomposites could significantly suppress tumor growth under NIR laser irradiation, as validated by and assessments. Combined with outstanding biocompatibility, the constructed nanosystem holds great potential in combinational antitumor therapy.
得益于多种治疗模式的结合，具有协同策略的功能化纳米平台在癌症治疗中引起了极大的兴趣。在此，我们构建了一种基于工程化的可生物降解的中空介孔有机硅纳米粒子（HMON）的纳米平台，用于肿瘤的光热增强化疗。我们首次证明，HMON 可以作为共递送紫杉醇和光热剂新型吲哚菁绿（IR820）的纳米载体，记为紫杉醇/IR820@HMONs-PEG。所制备的纳米系统表现出 28.4%的高紫杉醇载药能力，远高于大多数负载紫杉醇的纳米制剂。此外，将硫醚键（S-S）引入 HMONs 的骨架中，使它们具有 GSH 响应的生物降解行为，导致在肿瘤还原微环境下药物的可控释放，并阻碍紫杉醇的过早释放。在近红外激光照射下，所得共递药纳米系统表现出由 IR820 产生的优异的光热性能。构建的纳米复合材料在近红外激光照射下能显著抑制肿瘤生长，通过 和 评估得到验证。结合出色的生物相容性，所构建的纳米系统在联合抗肿瘤治疗中具有巨大的潜力。
