在膜性肾病中未能将单核吞噬细胞系统功能与HLA - A、B、C、DR、DQ抗原联系起来。

Failure to relate mononuclear phagocyte system function to HLA-A, B, C, DR, DQ antigens in membranous nephropathy.

作者信息

Roccatello D, Coppo R, Amoroso A, Curtoni E S, Martina G, Basolo B, Amore A, Rollino C, Picciotto G, Cordonnier D

出版信息

Am J Kidney Dis. 1987 Jun;9(6):470-5. doi: 10.1016/s0272-6386(87)80073-2.

Abstract

Nineteen patients with idiopathic membranous nephropathy were typed for HLA pattern and analyzed for the Fc receptor function of splenic macrophages by detecting in vivo the clearance of IgG-sensitized 51Cr-labelled autologous erythrocytes. Seven out of 19 patients were found to have a macrophage dysfunction. This defect was not related to any HLA-A, B, C, DR, DQ antigen tested nor to the levels of IgG-containing immune complexes, as detected by a Clq solid phase test, nor to the magnitude of proteinuria. Since HLA-B8 and HLA-DR3 antigens were significantly more frequent in patients than in the control group, the factors that may impair the macrophage system in individuals predisposed to this nephropathy are discussed.

摘要

对19例特发性膜性肾病患者进行了HLA分型，并通过在体内检测IgG致敏的51Cr标记自体红细胞的清除情况，分析了脾巨噬细胞的Fc受体功能。19例患者中有7例被发现存在巨噬细胞功能障碍。这种缺陷与所检测的任何HLA - A、B、C、DR、DQ抗原均无关，与通过Clq固相试验检测的含IgG免疫复合物水平无关，也与蛋白尿的程度无关。由于HLA - B8和HLA - DR3抗原在患者中显著多于对照组，因此讨论了可能在易患这种肾病的个体中损害巨噬细胞系统的因素。