Departments of Physiology and Pharmacology, Cardiac Sciences & Clinical Neurosciences, Libin Cardiovascular Institute of Alberta, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Department of Neurology, Clinical Hospital Center Split, Split, Croatia.
Appl Physiol Nutr Metab. 2022 Mar;47(3):269-277. doi: 10.1139/apnm-2021-0523. Epub 2021 Nov 5.
Individuals with cervical spinal cord injury (SCI) are at an increased risk for cardiovascular disease. Exercise is well-established for preventing cardiovascular disease; however, there are limited straightforward and safe exercise approaches for increasing the activity of the cardiorespiratory system after cervical SCI. The objective of this study was to investigate the cardiorespiratory response to passive leg cycling in people with cervical SCI. Beat-by-beat blood pressure, heart rate, and cerebral blood flow were measured before and throughout 10 minutes of cycling in 11 people with SCI. Femoral artery flow-mediated dilation was also assessed before and immediately after passive cycling. Safety was monitored throughout all study visits. Passive cycling elevated systolic blood pressure (5 ± 2 mm Hg), mean arterial pressure (5 ± 3 mm Hg), stroke volume (2.4 ± 0.8 mL), heart rate (2 ± 1 beats/min) and cardiac output (0.3 ± 0.07 L/min; all < 0.05). Minute ventilation (0.67 ± 0.23 L/min), tidal volume (70 ± 30 mL) and end-tidal PO (2.6 ± 1.23 mm Hg) also increased (all < 0.05). Endothelial function was improved immediately after exercise (1.62 ± 0.13%, < 0.01). Passive cycling resulted in an incidence of autonomic dysreflexia. Therefore, passive leg cycling increased the activity of the cardiorespiratory system and improved endothelial function, indicating it may be a beneficial exercise intervention for the cardiovascular and respiratory systems in people with cervical SCI. Passive leg cycling increases the activity of the cardiorespiratory system and improves markers of cardiovascular health in cervical SCI. Passive leg cycling exercise is an effective, low-cost, practical, alternative exercise modality for people with cervical SCI.
脊髓损伤（SCI）患者患心血管疾病的风险增加。运动对于预防心血管疾病是行之有效的；然而，对于增加颈 SCI 后心肺系统的活动，目前还没有直接且安全的运动方法。本研究旨在探讨被动腿循环对颈 SCI 患者心肺反应的影响。11 名 SCI 患者在进行 10 分钟的被动循环前和整个过程中，测量了逐搏血压、心率和脑血流。还在被动循环前后评估了股动脉血流介导的扩张。在所有研究访问期间都监测了安全性。被动循环使收缩压（5±2mmHg）、平均动脉压（5±3mmHg）、每搏量（2.4±0.8mL）、心率（2±1 次/分钟）和心输出量（0.3±0.07L/min；均<0.05）升高。分钟通气量（0.67±0.23L/min）、潮气量（70±30mL）和呼气末 PO（2.6±1.23mmHg）也增加（均<0.05）。运动后内皮功能立即改善（1.62±0.13%，<0.01）。被动循环导致自主神经反射异常的发生率。因此，被动腿循环增加了心肺系统的活动，改善了内皮功能，表明它可能是颈 SCI 患者心血管和呼吸系统的有益运动干预措施。被动腿循环增加了颈 SCI 患者心肺系统的活动，改善了心血管健康的标志物。被动腿循环运动是一种有效、低成本、实用的颈 SCI 患者替代运动方式。
