过继输注肿瘤特异性 Th9 细胞可消除异质性抗原表达的肿瘤细胞。
Adoptive transfer of tumor-specific Th9 cells eradicates heterogeneous antigen-expressing tumor cells.
机构信息
Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, VIC, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville 3010, Australia.
Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, VIC, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville 3010, Australia.
出版信息
Cancer Cell. 2021 Dec 13;39(12):1564-1566. doi: 10.1016/j.ccell.2021.10.013. Epub 2021 Nov 4.
In this issue of Cancer Cell, Xue et al. demonstrate that adoptive transfer of tumor-specific Th9 cells can eradicate established tumors containing antigen-loss-variant cells (ALVs) through both direct killing and bystander effects mediated by intratumoral accumulation of extracellular ATP (eATP) that promotes monocyte infiltration and stimulation of IFNα/β production.
在本期《癌细胞》中，薛等人证明，通过过继转移肿瘤特异性 Th9 细胞，可以通过直接杀伤和肿瘤内积累的细胞外 ATP（eATP）介导的旁观者效应来清除含有抗原丢失变异细胞（ALV）的已建立肿瘤，eATP 促进单核细胞浸润和 IFNα/β 的产生。
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