Department of Family and Community Medicine, College of Medicine - Tucson, University of Arizona, Tucson, AZ, USA.
Department of Family and Community Medicine, College of Medicine - Tucson, University of Arizona, Tucson, AZ, USA.
Addict Behav. 2022 Feb;125:107153. doi: 10.1016/j.addbeh.2021.107153. Epub 2021 Oct 14.
Menstrual phase influences cigarette smoking-related outcomes. Telephone-based cessation programs (e.g., quitlines) may incorporate the role of the menstrual cycle in an effort to tailor interventions for women.
The goal of this preliminary randomized clinical trial was to examine the feasibility and acceptability of timing quit date to menstrual phase in women in a quitline setting.
We recruited treatment-seeking women with regular menstrual cycles between the ages of 18-40 years. Participants were randomized to the follicular phase (FP; quit date set 6-8 days post onset of menses) or standard of care (SC; no menstrual timing of quit date). All participants received four weeks of nicotine replacement therapy transdermal patch concurrent with six weeks of telephone-based counseling. We explored self-reported and biochemically-verified seven-day point prevalence abstinence at end-of-treatment and three-month follow-up.
Participants (n = 119; FP: n = 58, SC: n = 61) were, on average, 33.4 years old and smoked 13.6 cigarettes/day. The median number of counseling sessions completed was 6 out of 6 available, and 66% of participants completed the intervention. Over 90% of participants reported they would recommend this study to friends/family. Cessation rates did not significantly vary by randomization.
Results of this preliminary trial indicate that timing quit date to FP is an acceptable and feasible approach to address smoking cessation in women of reproductive age. While we observed similar smoking cessation rates between groups, this preliminary study was not fully powered to determine efficacy. Therefore, the feasibility and acceptability results indicate that a fully-powered efficacy trial is warranted.
月经周期会影响与吸烟有关的结果。基于电话的戒烟项目（如戒烟热线）可能会考虑到月经周期的作用，以便针对女性定制干预措施。
本初步随机临床试验的目的是研究在戒烟热线环境中，根据女性的月经周期来安排戒烟日期的可行性和可接受性。
我们招募了年龄在 18-40 岁之间、月经周期规律的有治疗需求的女性。参与者被随机分配到卵泡期（FP；在月经开始后 6-8 天设定戒烟日期）或标准护理（SC；不考虑月经周期来安排戒烟日期）。所有参与者在接受六周电话咨询的同时，都接受四周尼古丁替代疗法经皮贴片治疗。我们在治疗结束时和三个月随访时探索了自我报告和生物化学验证的七天点患病率戒烟率。
参与者（n=119；FP：n=58，SC：n=61）的平均年龄为 33.4 岁，平均每天吸烟 13.6 支。完成的咨询次数中位数为 6 次，共 6 次，有 66%的参与者完成了干预。超过 90%的参与者表示他们会向朋友/家人推荐这项研究。随机分组后，戒烟率没有显著差异。
这项初步试验的结果表明，根据卵泡期来安排戒烟日期是一种可以接受且可行的方法，可用于解决育龄女性的吸烟问题。虽然我们观察到两组之间的戒烟率相似，但本初步研究的效力尚未完全确定。因此，这些可行性和可接受性结果表明，有必要进行一项充分的疗效试验。
