Sautter F, Garver D L, Zemlan F P, Hirschowitz J
Biol Psychiatry. 1987 Jun;22(6):717-24. doi: 10.1016/0006-3223(87)90203-4.
Sixty-five psychotic probands were divided into three groups (low, intermediate, and high) on the basis of the GH response to the dopamine receptor agonist apomorphine. Two hundred and sixty-five first-degree relatives of the probands were diagnosed according to SADS-DSM-III methods, and the relatives of the three groups of probands were compared so as to detect familial differences in the incidence of DSM-III Axis I disorders, schizotypal personality disorder, and antisocial personality. Although the morbid risk of schizophrenic spectrum disorder was only 3.1% in the relatives of the high GH probands, the morbid risk for disorders of the schizophrenic spectrum was 17.0% and 10.7% in the relatives of the intermediate and low GH probands, respectively. These data provide preliminary evidence that there may be a psychotic subtype that is characterized by supersensitivity of the dopamine system that is familially, and perhaps genetically, distinct from the bulk of the schizophrenias.
根据生长激素（GH）对多巴胺受体激动剂阿扑吗啡的反应，将65名精神病先证者分为三组（低、中、高）。根据SADS-DSM-III方法对先证者的265名一级亲属进行诊断，并对三组先证者的亲属进行比较，以检测DSM-III轴I障碍、分裂型人格障碍和反社会人格在家族发病率上的差异。尽管高GH先证者亲属中精神分裂症谱系障碍的患病风险仅为3.1%，但中、低GH先证者亲属中精神分裂症谱系障碍的患病风险分别为17.0%和10.7%。这些数据提供了初步证据，表明可能存在一种以多巴胺系统超敏为特征的精神病亚型，这种亚型在家族中，也许在基因上，与大多数精神分裂症不同。
