动态AHR-CYP1A1信号网络中的关键因素有哪些？ - Suppr | 超能文献

Which are the Keystones in the Dynamic AHR-CYP1A1 Signaling Network?

作者信息

Rannug John Ulf

机构信息

Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.

出版信息

J Invest Dermatol. 2022 Jun;142(6):1758-1760. doi: 10.1016/j.jid.2021.10.022. Epub 2021 Nov 3.

DOI:10.1016/j.jid.2021.10.022

Abstract

摘要

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1

Which are the Keystones in the Dynamic AHR-CYP1A1 Signaling Network?动态AHR-CYP1A1信号网络中的关键因素有哪些？

J Invest Dermatol. 2022 Jun;142(6):1758-1760. doi: 10.1016/j.jid.2021.10.022. Epub 2021 Nov 3.

2

Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines.缺氧干扰 PCB126 诱导的人皮肤和肝源性细胞系中芳香烃受体信号和 CYP1A1 表达。

Toxicol Appl Pharmacol. 2014 Feb 1;274(3):408-16. doi: 10.1016/j.taap.2013.12.002. Epub 2013 Dec 16.

3

Coordinate regulation of cytochrome P450 1a1 expression in mouse liver by the aryl hydrocarbon receptor and the beta-catenin pathway.芳烃受体和β-连环蛋白通路对小鼠肝细胞色素 P450 1a1 表达的协调调控。

Toxicol Sci. 2011 Jul;122(1):16-25. doi: 10.1093/toxsci/kfr080. Epub 2011 Apr 16.

4

Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation.芳烃受体/细胞色素P450 1A1途径通过抑制PTEN以及激活β-连环蛋白和Akt介导乳腺癌干细胞的扩增。

Mol Cancer. 2017 Jan 19;16(1):14. doi: 10.1186/s12943-016-0570-y.

5

Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms.甲基化五价砷代谢产物是双功能诱导剂，因为它们通过芳烃受体（AhR）和核因子E2相关因子2（Nrf2）依赖的机制诱导细胞色素P450 1A1和NAD（P）H：醌氧化还原酶。

Free Radic Biol Med. 2014 Feb;67:171-87. doi: 10.1016/j.freeradbiomed.2013.10.810. Epub 2013 Oct 24.

6

Cytochrome P450 1A1 gene regulation by UVB involves crosstalk between the aryl hydrocarbon receptor and nuclear factor kappaB.UVB 通过芳香烃受体和核因子 κB 之间的串扰调节细胞色素 P450 1A1 基因。

Chem Biol Interact. 2010 Mar 30;184(3):466-73. doi: 10.1016/j.cbi.2010.01.038. Epub 2010 Feb 1.

7

Effects of human blood levels of two PAH mixtures on the AHR signalling activation pathway and CYP1A1 and COMT target genes in granulosa non-tumor and granulosa tumor cell lines.两种多环芳烃混合物的人体血液水平对颗粒非肿瘤细胞系和颗粒肿瘤细胞系中芳烃受体（AHR）信号激活途径以及CYP1A1和儿茶酚-O-甲基转移酶（COMT）靶基因的影响。

Toxicology. 2017 Aug 15;389:1-12. doi: 10.1016/j.tox.2017.07.003. Epub 2017 Jul 11.

8

Aryl hydrocarbon receptor activation of an antitumor aminoflavone: basis of selective toxicity for MCF-7 breast tumor cells.一种抗肿瘤氨基黄酮的芳基烃受体激活：MCF-7乳腺肿瘤细胞选择性毒性的基础

Mol Cancer Ther. 2004 Jun;3(6):715-25.

9

Induction of CYP1A1. The AhR/DRE paradigm: transcription, receptor regulation, and expanding biological roles.CYP1A1的诱导。芳烃受体/二噁英响应元件模式：转录、受体调控及不断扩展的生物学作用。

Curr Drug Metab. 2001 Jun;2(2):149-64. doi: 10.2174/1389200013338603.

10

Polychlorinated diphenyl sulfides can induce ROS and genotoxicity via the AhR-CYP1A1 pathway.多氯联苯硫醚可通过 AhR-CYP1A1 途径诱导活性氧和遗传毒性。

Chemosphere. 2019 May;223:165-170. doi: 10.1016/j.chemosphere.2019.01.169. Epub 2019 Feb 1.

引用本文的文献

1

PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis.PM2.5 通过 KLF9/CYP1A1 转录轴诱导滋养细胞氧化应激和线粒体凋亡导致不良妊娠结局。

Elife. 2023 Sep 22;12:e85944. doi: 10.7554/eLife.85944.

2

Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases.芳烃受体：慢性炎症性皮肤病治疗靶点的证据

Biomedicines. 2022 May 7;10(5):1087. doi: 10.3390/biomedicines10051087.