依诺沙星与华法林的相互作用：药代动力学和立体化学方面。

Enoxacin-warfarin interaction: pharmacokinetic and stereochemical aspects.

作者信息

Toon S, Hopkins K J, Garstang F M, Aarons L, Sedman A, Rowland M

出版信息

Clin Pharmacol Ther. 1987 Jul;42(1):33-41. doi: 10.1038/clpt.1987.104.

DOI:10.1038/clpt.1987.104

Abstract

The interaction between the new quinoline-azaquinoline antibiotic enoxacin and the oral anticoagulant warfarin was investigated in six healthy male volunteers. Enoxacin was found not to affect the hypoprothrombinemic response produced by warfarin but did produce a decrease in the clearance of the less pharmacologically potent enantiomer of warfarin, (R)-warfarin. The decreased clearance of (R)-warfarin produced by concomitant enoxacin administration was found to be a consequence of inhibition by enoxacin of the (R)-6-hydroxywarfarin metabolic pathway.

摘要

在六名健康男性志愿者中研究了新型喹啉 - 氮杂喹啉抗生素依诺沙星与口服抗凝剂华法林之间的相互作用。发现依诺沙星不影响华法林产生的低凝血酶原血症反应，但确实使华法林药理活性较低的对映体（R）-华法林的清除率降低。发现同时给予依诺沙星导致（R）-华法林清除率降低是由于依诺沙星抑制了（R）-6-羟基华法林代谢途径。