Zeis B M
Chemotherapy. 1987;33(3):204-10. doi: 10.1159/000238496.
The effects of the anti-tuberculosis (TB) drugs isoniazid, rifampicin, streptomycin, pyrazinamide and ethambutol on the synthesis of prostaglandin E2 (PGE2) by polymorphonuclear leucocytes were investigated. Only rifampicin at a concentration of 100 micrograms/ml caused statistically significant stimulation of PGE2 production whereas the other compounds had no effect. Immunomodulatory properties of the compounds individually and in combination were investigated using phytohaemagglutinin-stimulated mononuclear leucocyte transformations. Rifampicin caused dose-dependent inhibition of blastogenesis and combinations containing this agent also had an inhibitory effect. The prostaglandin synthesis inhibitor indomethacin caused stimulation of phytohaemagglutinin responsiveness and this effect was not influenced by the presence of the anti-TB drugs.
研究了抗结核药物异烟肼、利福平、链霉素、吡嗪酰胺和乙胺丁醇对多形核白细胞合成前列腺素E2（PGE2）的影响。仅浓度为100微克/毫升的利福平对PGE2的产生有统计学上显著的刺激作用，而其他化合物则无作用。使用植物血凝素刺激的单核白细胞转化来研究这些化合物单独及联合使用时的免疫调节特性。利福平引起剂量依赖性的母细胞生成抑制，含有该药物的组合也有抑制作用。前列腺素合成抑制剂吲哚美辛可刺激植物血凝素反应性，且这种作用不受抗结核药物存在的影响。
