阿尔茨海默病和帕金森病血液生物标志物的超灵敏检测：一项系统综述

Ultrasensitive detection of blood biomarkers of Alzheimer's and Parkinson's diseases: a systematic review.

作者信息

Singh Kailash, Cheung Bernard My, Xu Aimin

机构信息

State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China.

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.

出版信息

Biomark Med. 2021 Dec;15(17):1693-1708. doi: 10.2217/bmm-2021-0219. Epub 2021 Nov 8.

DOI:10.2217/bmm-2021-0219

PMID:34743546

Abstract

Neurodegenerative disorders are a global health burden with costly and invasive diagnoses relying on brain imaging technology or CSF-based biomarkers. Therefore, considerable efforts to identify blood-biomarkers for Alzheimer's (AD) and Parkinson's diseases (PD) are ongoing. This review evaluates the blood biomarkers for AD and PD for their diagnostic value. This study systematically reviewed articles published between July 1984 and February 2021. Among 1266 papers, we selected 42 studies for a systematic review and 23 studies for meta-analysis. Our analysis highlights P-tau181, T-tau and Nfl as promising blood biomarkers for AD diagnosis. Nfl levels were consistently raised in 16 AD and three PD cohorts. P-tau181 and T-tau were also significantly increased in 12 and eight AD cohorts, respectively.

摘要

神经退行性疾病是一项全球性的健康负担，其诊断成本高昂且具有侵入性，依赖于脑成像技术或基于脑脊液的生物标志物。因此，目前正在进行大量工作以寻找阿尔茨海默病（AD）和帕金森病（PD）的血液生物标志物。本综述评估了用于AD和PD诊断的血液生物标志物的价值。本研究系统回顾了1984年7月至2021年2月发表的文章。在1266篇论文中，我们选择了42项研究进行系统综述，23项研究进行荟萃分析。我们的分析强调P-tau181、T-tau和Nfl是用于AD诊断的有前景的血液生物标志物。在16个AD队列和3个PD队列中，Nfl水平持续升高。在12个和8个AD队列中，P-tau181和T-tau也分别显著升高。