Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China.
Tianjin Key Laboratory of Cerebrovascular and of neurodegenerative diseases, Tianjin Dementia Institute, Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.
J Alzheimers Dis. 2021;84(4):1657-1667. doi: 10.3233/JAD-210611.
Dementia and hyperhidrosis (HH) are common in the elderly while there is little research to investigate the association between them.
To clarify a possible association between HH and dementia in population of adults ≥65 years old in China.
A cross-sectional survey for elderly adults ≥65 years old was conducted from April to December 2019. A total of 5,958 participants were analyzed after two phases investigation. Goodness-of-fit tests (Pearson and deviance) were used to estimate the dispersion parameter and examine the adequacy of the models. Logistic and linear regression analyses were used to evaluate the association between HH and dementia.
The overall prevalence of all-cause dementia was 10.17%, that of dementia with Lewy bodies (DLB) was 1.41%, and HH was 14.97%. Prevalence rates of HH were higher in participants with dementia and DLB. There was a significant positive relationship between HH duration and MMSE score (r = 0.207, p < 0.001, Durbin-Watson test = 1.806). Participants with HH were 1.275 (95% CI: 1.015-1.601, p = 0.037) times to have dementia, and 3.616 (95% CI: 2.267-5.767, p < 0.001) times to suffer from DLB than those without HH. Pearson and deviance chi square tests did not indicate overdispersion (p > 0.05 in the logistic regression models).
HH was common in the Chinese population ≥65 years old. It can increase the risk of dementia, particularly in DLB, in the elderly. It is important to improve the awareness of HH among dermatologists and neurologists.
痴呆症和多汗症（HH）在老年人中很常见，但很少有研究调查它们之间的关联。
阐明 HH 与中国 65 岁以上人群中痴呆症之间可能存在的关联。
对 2019 年 4 月至 12 月期间的 65 岁以上老年人进行了横断面调查。经过两阶段调查，共分析了 5958 名参与者。采用拟合优度检验（Pearson 和偏差）来估计离散参数，并检查模型的充分性。采用逻辑回归和线性回归分析评估 HH 与痴呆症之间的关系。
总痴呆症的患病率为 10.17%，路易体痴呆症（DLB）的患病率为 1.41%，HH 的患病率为 14.97%。HH 患病率在痴呆症和 DLB 患者中较高。HH 持续时间与 MMSE 评分呈显著正相关（r=0.207，p<0.001，Durbin-Watson 检验=1.806）。HH 患者发生痴呆症的风险是无 HH 患者的 1.275 倍（95%CI：1.015-1.601，p=0.037），发生 DLB 的风险是无 HH 患者的 3.616 倍（95%CI：2.267-5.767，p<0.001）。逻辑回归模型中的 Pearson 和偏差卡方检验未显示过度离散（p>0.05）。
HH 在我国 65 岁以上人群中较为常见。它会增加老年人患痴呆症的风险，尤其是 DLB。皮肤科医生和神经科医生应提高对 HH 的认识。
