1Department of Psychiatry, Dr. Ivan Barbot Neuropsychiatric Hospital, Popovača, Croatia; 2Department of Psychiatry, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia.
Acta Clin Croat. 2021 Jun;60(2):304-308. doi: 10.20471/acc.2021.60.02.18.
We present a case of a patient with treatment resistant hallucinatory experiences with incidental finding of an arachnoid cyst localized in the posterior infratentorial cranial fossa dorsally to the cerebellum. Psychological testing revealed significant deficit of cognitive functions to the level of mild intellectual disability in a person that had previously finished high school with good grades. A combination of clozapine and lamotrigine led to significant improvement in mood and reduction of hallucinations, but without improvement in cognitive functions. We also performed a literature review of previously published case reports or case series of co-occurring posterior fossa arachnoid cyst and schizophrenia or psychosis or psychiatric symptoms using PubMed search and discuss some controversies considering their treatment outcome.
我们报告了 1 例治疗抵抗性幻觉患者,偶然发现蛛网膜囊肿位于小脑后部颅后窝,位于小脑上方。心理测试显示,在以前成绩优异完成高中的人身上,认知功能明显存在缺陷,达到轻度智力残疾的程度。氯氮平联合拉莫三嗪治疗可显著改善情绪,减少幻觉,但对认知功能无改善。我们还使用 PubMed 搜索了先前发表的关于后颅窝蛛网膜囊肿伴精神分裂症或精神病或精神症状的病例报告或病例系列,并对其治疗结果进行了一些争议的讨论。