Sharma Saniya, Kumar Narender, Bihana Ishwar, Uppal Varun, Ahluwalia Jasmina, Naseem Shano, Varma Neelam, Rana Surinder Singh
Department of Hematology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012 India.
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012 India.
Indian J Hematol Blood Transfus. 2021 Oct;37(4):593-599. doi: 10.1007/s12288-021-01400-5. Epub 2021 Apr 13.
Splanchnic vein thrombosis (SVT) is a rare and lethal form of venous thrombosis. The role of platelet indices () is not well studied in SVT. The present study was aimed to assess if the have a significant association with SVT. This was a prospective case control study from coagulation laboratory of Hematology department. A total 100 cases of SVT and 80 controls were screened for (MPV, PCT & PDW) and platelet count (PC) along with routine thrombophilic risk factors. The SVT cases were divided into 3 subgroups, that comprised of EHPVO/ PVT (n = 69), BCS (n = 27), and MVT (n = 4). The mean PC and PCT were significantly lower in patients than the controls. The PDW was significantly higher in cases than in the controls and MPV was relatively higher in cases however did not show statistical significance. In addition, 16 patients were found to have deranged thrombophilic risk factors. Among these, 8 cases had inherited risk factors (2: FVL; 5: PC; 1: PS) and 8 cases had acquired risk factors (2: APL; and 5: multiple factors and one case had both FVL mutation and APL positivity). The PDW and PCT together with PC were found to significantly differ in SVT cases than in controls, particularly in idiopathic cases. It may be worthwhile to explore the utility of as a potential risk factor in SVT.
The online version contains supplementary material available at (10.1007/s12288-021-01400-5).
内脏静脉血栓形成（SVT）是一种罕见且致命的静脉血栓形成形式。血小板指标在SVT中的作用尚未得到充分研究。本研究旨在评估血小板指标是否与SVT存在显著关联。这是一项来自血液科凝血实验室的前瞻性病例对照研究。共筛选了100例SVT病例和80例对照，检测其血小板指标（平均血小板体积、血小板压积和血小板分布宽度）、血小板计数以及常规血栓形成倾向风险因素。SVT病例分为3个亚组，包括肝外型门静脉闭塞/门静脉血栓形成（n = 69）、布加综合征（n = 27）和肠系膜静脉血栓形成（n = 4）。患者的平均血小板计数和血小板压积显著低于对照组。病例组的血小板分布宽度显著高于对照组，病例组的平均血小板体积相对较高，但无统计学意义。此外，发现16例患者存在异常的血栓形成倾向风险因素。其中，8例有遗传风险因素（2例：因子V Leiden突变；5例：蛋白C缺乏；1例：蛋白S缺乏），8例有获得性风险因素（2例：抗磷脂抗体综合征；5例：多种因素，1例同时存在因子V Leiden突变和抗磷脂抗体综合征阳性）。发现血小板分布宽度、血小板压积以及血小板计数在SVT病例组与对照组之间存在显著差异，尤其是在特发性病例中。探讨血小板指标作为SVT潜在风险因素的效用可能是值得的。
在线版本包含可在（10.1007/s12288-021-01400-5）获取的补充材料。
