Al-Benna S
Division of Plastic Surgery, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.
Ann Burns Fire Disasters. 2021 Sep 30;34(3):226-234.
Toxic epidermal necrolysis syndrome (TENS) is a rare medical emergency associated with high morbidity and mortality. At present, there is no agreement regarding specific treatments for this disease. The aim of this study is to determine the outcome of patients with TENS using a treatment protocol that did not include the use of intravenous immunoglobulin or systemic steroids. This is a retrospective study of all patients diagnosed with TENS admitted to a tertiary burns centre from 2015-2017. Twelve cases were identified with a mean age of 46±8 years. Mean total body surface area affected was 51±9%. The SCORTEN index was 3.4±0.3 (range 2-5) and predicted 3 deaths in this cohort. Overall mortality was 25%. This study casts no doubt on the prognostic validity of SCORTEN. No specific TENS treatment has been unequivocally proven to be effective.
中毒性表皮坏死松解症（TENS）是一种罕见的医疗急症，发病率和死亡率都很高。目前，对于这种疾病的具体治疗方法尚无共识。本研究的目的是使用一种不包括静脉注射免疫球蛋白或全身用类固醇的治疗方案来确定TENS患者的治疗结果。这是一项对2015年至2017年入住三级烧伤中心的所有诊断为TENS的患者进行的回顾性研究。共确定了12例患者，平均年龄为46±8岁。平均受影响的体表面积为51±9%。SCORTEN指数为3.4±0.3（范围2 - 5），并预测该队列中有3例死亡。总体死亡率为25%。本研究对SCORTEN的预后有效性毫无疑问。尚无明确证据证明任何特定的TENS治疗方法是有效的。
