Gao Wenwen, Yang Dong, Zhang Zhe, Du Lei, Liu Bing, Liu Jian, Chen Yue, Wang Yige, Liu Xiuxiu, Yang Aocai, Lv Kuan, Xue Jiajia, Ma Guolin
Department of Radiology, China-Japan Friendship Hospital, Beijing, China.
Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China.
Front Hum Neurosci. 2021 Oct 22;15:770107. doi: 10.3389/fnhum.2021.770107. eCollection 2021.
Hemifacial spasm (HFS) is a kind of motor disorder, and the striatum plays a significant role in motor function. The purpose of this study was to explore the alterations of the cortical-striatal network in HFS using resting-state functional magnetic resonance imaging (fMRI). The fMRI data of 30 adult patients with primary unilateral HFS (15 left-side and 15 right-side) and 30 healthy controls were collected. Six subregions of the striatum in each hemisphere were selected for functional connectivity (FC) analysis. One-sample test was used to analyze the intragroup FC of the HFS group and the control group. Two-sample -test was used to compare the difference of FC between the two groups. The correlation between the abnormal FC and severity of HFS was evaluated by using the Spearman correlation analysis. Compared with the controls, the striatal subregions had altered FC with motor and orbitofrontal cortex in patients with HFS. The altered FC between striatal subregions and motor cortex was correlated with the spasm severity in patients with HFS. The FC of the cortical-striatal network was altered in primary HFS, and these alterations were correlated with the severity of HFS. This study indicated that the cortical-striatal network may play different roles in the underlying pathological mechanism of HFS.
面肌痉挛（HFS）是一种运动障碍，纹状体在运动功能中起重要作用。本研究的目的是使用静息态功能磁共振成像（fMRI）探索面肌痉挛患者皮质-纹状体网络的改变。收集了30例成年原发性单侧面肌痉挛患者（15例左侧和15例右侧）和30名健康对照者的fMRI数据。选择每个半球纹状体的六个亚区域进行功能连接（FC）分析。采用单样本检验分析面肌痉挛组和对照组的组内FC。采用双样本检验比较两组之间FC的差异。采用Spearman相关分析评估异常FC与面肌痉挛严重程度之间的相关性。与对照组相比，面肌痉挛患者纹状体亚区域与运动和眶额皮质的FC发生了改变。纹状体亚区域与运动皮质之间改变的FC与面肌痉挛患者的痉挛严重程度相关。原发性面肌痉挛患者皮质-纹状体网络的FC发生了改变，且这些改变与面肌痉挛的严重程度相关。本研究表明，皮质-纹状体网络可能在面肌痉挛的潜在病理机制中发挥不同作用。
