Li Quan, Zhao Zhi, Xie Jingming, Zhang Ying, Li Tao, Wang Yingsong
Department of Orthopaedics, The Second Affiliated Hospital of Kunming Medical University, No. 112 Kunrui Road, Kunming 650101, Yunnan, China.
Evid Based Complement Alternat Med. 2021 Oct 29;2021:7008898. doi: 10.1155/2021/7008898. eCollection 2021.
To explore the relationship between (bone fusion associated protein) bone morphogenetic protein (BMP)2 and BMP9 and spinal function and quality of life in patients with severe scoliosis after posterior vertebral column resection (PVCR).
78 cases of severe scoliosis treated with PVCR surgery in our hospital from January 2015 to April 2018 were selected and set as the observation group, and 80 health examiners in the same period were selected and set as the control group. The ELISA method was used to detect the levels of BMP2 and BMP9 in the two groups. Also, the relationship between the recovery of spinal function, quality of life, and serum BMP2 and BMP9 in the observation group was analyzed. The receiver operating characteristic curve was used to evaluate the predictive value of BMP2 and BMP9 for complications after PVCR.
One month after PVCR, the serum BMP2 and BMP9 levels of patients with severe scoliosis were higher than those of healthy people ( < 0.05). One year after PVCR, Pearson correlation analysis showed that serum levels of BMP2 and BMP9 in patients with scoliosis were positively correlated with ODI scores ( = 0.778, < 0.001; = 0.746, < 0.001), SRS-22 scores ( = 0.758, < 0.001; = 0.722, < 0.001), and Cobb angle correction rate ( = 0.838, < 0.001; = 0.802, < 0.001).
The levels of BMP2 and BMP9 of patients with scoliosis after PVCR are higher than those of healthy people. After 1-year follow-up, the patients' serum BMP2 and BMP9 levels were positively correlated with spinal function recovery, quality of life, and surgical efficacy. Among them, BMP2 and BMP9 had the highest correlation with PVCR surgical efficacy. Paying attention to the serum BMP2 and BMP9 levels of patients with scoliosis has certain clinical significance.
探讨（骨融合相关蛋白）骨形态发生蛋白（BMP）2和BMP9与重度脊柱侧弯患者后路脊柱全椎体切除术（PVCR）后脊柱功能及生活质量的关系。
选取2015年1月至2018年4月在我院接受PVCR手术治疗的78例重度脊柱侧弯患者作为观察组，选取同期80名健康体检者作为对照组。采用酶联免疫吸附测定（ELISA）法检测两组患者BMP2和BMP9水平。同时，分析观察组患者脊柱功能恢复、生活质量与血清BMP2和BMP9之间的关系。采用受试者工作特征曲线评估BMP2和BMP9对PVCR术后并发症的预测价值。
PVCR术后1个月，重度脊柱侧弯患者血清BMP2和BMP9水平高于健康人（<0.05）。PVCR术后1年，Pearson相关性分析显示，脊柱侧弯患者血清BMP2和BMP9水平与脊柱功能障碍指数（ODI）评分呈正相关（r = 0.778，P < 0.001；r = 0.746，P < 0.001）、脊柱侧弯研究学会-22（SRS-22）评分呈正相关（r = 0.758，P < 0.001；r = 0.722，P < 0.001）以及Cobb角矫正率呈正相关（r = 0.838，P < 0.001；r = 0.802，P < 0.001）。
PVCR术后脊柱侧弯患者的BMP2和BMP9水平高于健康人。随访1年后，患者血清BMP2和BMP9水平与脊柱功能恢复、生活质量及手术疗效呈正相关。其中，BMP2和BMP9与PVCR手术疗效的相关性最高。关注脊柱侧弯患者血清BMP2和BMP9水平具有一定的临床意义。
