Rodríguez-Núñez Omar, Schucht Philippe, Hewer Ekkehard, Novikova Tatiana, Pierangelo Angelo
LPICM, CNRS, Ecole polytechnique, IP Paris, Palaiseau, 91128, France.
Department of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland.
Biomed Opt Express. 2021 Oct 1;12(10):6674-6685. doi: 10.1364/BOE.439754.
We suggest using the wide-field imaging Mueller polarimetry to contrast optically anisotropic fiber tracts of healthy brain white matter for the detection of brain tumor borders during neurosurgery. Our prior studies demonstrate that this polarimetric imaging modality detects correctly the in-plane orientation of brain white matter fiber tracts of a flat formalin-fixed thick brain specimen in reflection geometry [IEEE Trans. Med. Imaging39, 4376 (2020)10.1109/TMI.2020.3018439]. Here we present the results of polarimetric studies of large cross-sections of fresh calf brain in reflection geometry with a special focus on the impact of the adverse measurement conditions (e.g. complex surface topography, presence of blood, etc.) on the quality of polarimetric images and the detection performance of white matter fiber tracts and their in-plane orientation.
我们建议使用宽场成像穆勒偏振测量法来对比健康脑白质的光学各向异性纤维束，以便在神经外科手术中检测脑肿瘤边界。我们之前的研究表明，这种偏振成像方式能够在反射几何结构中正确检测扁平福尔马林固定厚脑标本的脑白质纤维束的面内方向[《IEEE医学成像汇刊》39, 4376 (2020)10.1109/TMI.2020.3018439]。在此，我们展示了在反射几何结构中对新鲜小牛脑大横截面进行偏振研究的结果，特别关注不利测量条件（如复杂的表面地形、血液的存在等）对偏振图像质量以及白质纤维束的检测性能及其面内方向的影响。
