Singh Sneha, Gogoi Anootpal, Kumar Ashish, Jagnade Rinku, Jain Gaurav, Rastogi Sanjay, Dutta Sanjay
Dept. of Periodontology, Mithila Minority Dental College and Hospital, India.
Dept. of Periodontology, Regional Dental College, Guwahati, Assam, India.
J Oral Biol Craniofac Res. 2022 Jan-Feb;12(1):22-26. doi: 10.1016/j.jobcr.2021.09.020. Epub 2021 Oct 5.
BACKGROUND/PURPOSE: This research aimed to compare the effects of systemically prescribed Lycopene as a monotherapy and as an alternative to scaling and root planing in patients with chronic gingivitis.
The participants were randomly assigned to one of two treatment groups: the experimental group (n = 50), which received 10 mg of Lycopene a day for two weeks, or the control group (n = 50) received a placebo for two weeks. For each category, quadrant distribution was randomized, with two quadrants receiving oral prophylaxis (OP) and two quadrants receiving no care (non-OP). At baseline, 1st, and 2nd weeks, the sulcus bleeding index, plaque index, gingival index, and salivary uric acid level were measured.
All clinical criteria, including SBI, PI, GI, and salivary uric acid levels, showed a statistically significant decline in all patient types. Both clinical parameters were significantly reduced (p < 0.001) in the OP-lycopene group relative to the non-OP-placebo group and non-OP lycopene group (p < 0.05). The PI value in the OP-lycopene group was statistically significantly lower (p < 0.001) than in the non-OP-placebo group; there was no statistically significant difference in the other groups. Salivary uric acid levels in the OP- and non-OP- lycopene groups were significantly lower (p < 0.001) than in the non-OP-placebo population.
Based on the findings of this study, Lycopene seems to have a bright future as a treatment option for plaque-induced generalized chronic marginal gingivitis. More research with a broad sample size and multicentre trials is required.
The article reveals the positive relationship between Lycopene and gingivitis. The analysis shows that a combination of systemically administered Lycopene with oral prophylaxis can be a valuable tool in treating chronic gingivitis and controlling respiratory oxidative stress.
背景/目的：本研究旨在比较系统性给予番茄红素作为单一疗法以及作为慢性牙龈炎患者龈下刮治和根面平整替代疗法的效果。
参与者被随机分配至两个治疗组之一：实验组（n = 50），每天服用10毫克番茄红素，持续两周；对照组（n = 50），服用安慰剂两周。对于每个类别，象限分布是随机的，两个象限接受口腔预防（OP），两个象限不接受护理（非OP）。在基线、第1周和第2周时，测量龈沟出血指数、菌斑指数、牙龈指数和唾液尿酸水平。
所有临床指标，包括SBI、PI、GI和唾液尿酸水平，在所有患者类型中均显示出统计学上的显著下降。与非OP - 安慰剂组和非OP番茄红素组相比，OP - 番茄红素组的两个临床参数均显著降低（p < 0.001）（p < 0.05）。OP - 番茄红素组的PI值在统计学上显著低于非OP - 安慰剂组（p < 0.001）；其他组之间无统计学显著差异。OP和非OP番茄红素组的唾液尿酸水平显著低于非OP - 安慰剂组人群（p < 0.001）。
基于本研究结果，番茄红素作为菌斑诱导的广泛性慢性边缘性牙龈炎的治疗选择似乎前景光明。需要进行更多具有广泛样本量的研究和多中心试验。
本文揭示了番茄红素与牙龈炎之间的正相关关系。分析表明，系统性给予番茄红素与口腔预防相结合可能是治疗慢性牙龈炎和控制呼吸道氧化应激的有效手段。
