Reddy Rajgopal R, Reddy Srinivas Gosla, Pandey Avni, Banala Bhavya, Bronkhorst Ewald M, Kuijpers-Jagtman Anne Marie
Cranio-maxillofacial Surgery, G.S.R. Hospital, Institute of Cranio-Maxillofacial and Facial Plastic Surgery, Vinay Nagar Colony, Saidabad, Hyderabad, India.
G.S.R. Hospital, Institute of Cranio-Maxillofacial and Facial Plastic Surgery, Vinay Nagar Colony, Saidabad, Hyderabad, India.
J Oral Biol Craniofac Res. 2022 Jan-Feb;12(1):27-32. doi: 10.1016/j.jobcr.2021.09.009. Epub 2021 Sep 30.
This parallel blocked randomized controlled trial was done in two groups of 30 patients each to determine if placement of an antibiotic oral pack on the hard palate after hard palatal fistula repair reduces nasal air emission and fistula re-occurrence. Group A had an oral pack on the hard palate for 5 days post-operatively while group B did not. In group A, percentage of nasal air emission was tested using nasometry with and without pack. Paired t-tests were performed to compare nasal emissions for patients with and without pack. Recurrence of fistulas after 6 months between group A and B was tested using odds ratio. Effect of nasal air emission on fistula rates was tested using paired t-tests. There was a significant increase (p < 0.0001) in nasal emission after removal of the pack in group A. Fistula re-occurrence tended to be higher in group B (no pack) than group A but this was not significant (p = 0.242). There was no correlation between nasal air emission and fistula rates. In patients with recurrent fistulae, placement of an oral pack after fistula repair diminishes nasal air emission. Whether this has an impact on re-occurrence of fistulae needs to be investigated further.
这项平行分组随机对照试验分为两组，每组30例患者，旨在确定硬腭瘘修复术后在硬腭放置抗生素口服药包是否能减少鼻腔漏气和瘘管复发。A组术后在硬腭放置口服药包5天，而B组未放置。在A组中，使用鼻测量法分别在放置药包前后测试鼻腔漏气的百分比。采用配对t检验比较放置药包和未放置药包的患者的鼻腔漏气情况。使用比值比检验A组和B组6个月后瘘管的复发情况。使用配对t检验测试鼻腔漏气对瘘管发生率的影响。A组取出药包后鼻腔漏气显著增加（p < 0.0001）。B组（未放置药包）的瘘管复发率往往高于A组，但差异不显著（p = 0.242）。鼻腔漏气与瘘管发生率之间无相关性。在复发性瘘管患者中，瘘管修复后放置口服药包可减少鼻腔漏气。这是否对瘘管复发有影响尚需进一步研究。
