Titov L P, Korvigo G V, Kharitonik G D, Semenov G V
Probl Endokrinol (Mosk). 1987 Mar-Apr;33(2):9-13.
The state of the complement system was studied in 91 patients with insulin dependent and in 47 patients with non-insulin dependent diabetes. A study was made of the quantity of hemolytically effective molecules of some components C2, C4, C3, C5 of classic and factors B and D of alternative pathway of activation. Complement components were studied for control in 51 healthy blood donors. Antigens B8 and B18 of the HLA-histocompatibility system were studied in parallel in 24 patients and 21 donors. A significantly raised level of components C3 and C4, factors B and D was revealed in the patients with insulin dependent diabetes as compared to the controls (p less than 0.05). In non-insulin dependent diabetes C4, factors B and D were significantly raised and the level of C5 was lowered (p less than 0.05). In the patients with insulin dependent diabetes having antigens B18 the level of C3 was raised and the level of C4 was lowered as compared to the controls. The level of factors B and D was also lower than that in the diabetic patients. An analysis of the content of the complement components in 31 diabetic patients with diabetic nephropathy indicated a decrease in the levels of components C3 and C5 and an increase in the content of C4 (p less than 0.001) as compared to the normal. Diabetes was accompanied by considerable variations as compared to normal values characterizing the state of the complement system and reflecting, to a certain extent, the main features of the pathogenesis of disease.
对91例胰岛素依赖型糖尿病患者和47例非胰岛素依赖型糖尿病患者的补体系统状态进行了研究。对经典途径某些成分C2、C4、C3、C5以及替代激活途径的因子B和D的溶血有效分子数量进行了研究。对51名健康献血者的补体成分进行了对照研究。同时对24例患者和21名献血者的HLA组织相容性系统的抗原B8和B18进行了研究。与对照组相比，胰岛素依赖型糖尿病患者的C3、C4、因子B和D水平显著升高（p<0.05）。在非胰岛素依赖型糖尿病中，C4、因子B和D显著升高，C5水平降低（p<0.05）。与对照组相比，具有抗原B18的胰岛素依赖型糖尿病患者C3水平升高，C4水平降低。因子B和D的水平也低于糖尿病患者。对31例糖尿病肾病患者的补体成分含量分析表明，与正常相比，C3和C5水平降低，C4含量增加（p<0.001）。与正常数值相比，糖尿病伴随着补体系统状态的显著变化，在一定程度上反映了疾病发病机制的主要特征。
