Jacoby Elad, Zloto Ofira, Vishnevskia Dai Vicktoria
Division of Pediatric Hematology, Oncology and BMT, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Am J Ophthalmol Case Rep. 2021 Oct 22;24:101223. doi: 10.1016/j.ajoc.2021.101223. eCollection 2021 Dec.
A unique image of anterior chamber infiltration in a 2-year-infant with leukemia, treated with CD19 CAR T cells. Despite significant lymphopenia and resemblance of fungal infection initially, biopsy and cytologic analysis from anterior chamber fluid confirmed that this was CAR T-cell infiltration, likely targeting microscopic leukemia, unknown to us treating physicians. This is a unique case in 2 aspects: first, to state the high quality of CAR T-cell trafficking; and second - given the wide use of these cells currently, this image may help educate clinicians regarding this potential diagnosis.
一名接受CD19嵌合抗原受体T细胞（CAR T细胞）治疗的2岁白血病婴儿前房浸润的独特图像。尽管最初存在明显的淋巴细胞减少且类似真菌感染，但前房液的活检和细胞学分析证实这是CAR T细胞浸润，可能靶向微观层面的白血病，这对我们治疗医生来说是未知的。该病例在两个方面具有独特性：第一，表明CAR T细胞迁移的高质量；第二，鉴于目前这些细胞的广泛应用，这一图像可能有助于教育临床医生了解这种潜在的诊断。
