Department of Pediatric and Congenital Heart Surgery, 69106Onassis Cardiac Center, Athens, Greece.
Department of Cardiac Surgery, 54498Ghent University Hospital, Gent, Belgium.
Asian Cardiovasc Thorac Ann. 2022 Jul;30(6):627-634. doi: 10.1177/02184923211056711. Epub 2021 Nov 6.
Fontan circulation is a well-established palliation in patients with functional single ventricles. Absence of a sub-pulmonary pumping chamber creates a unique physiology in which blood flow is mainly guided by negative intrathoracic and elevated central venous pressures. Various pulmonary anatomic or pathophysiologic changes can jeopardize optimal Fontan circulation. Long-term survival of patients who have undergone the contemporary total cavopulmonary connection is satisfactory. Thorough literature review in conjunction with accumulated clinical experience can lead clinicians to extract conclusions regarding Fontan and lung interactions indicating the purpose of this review.
法洛四联症是功能性单心室患者的一种成熟的姑息治疗方法。由于缺乏肺下腔泵腔，血液主要受胸内负压和中心静脉压升高的影响，形成了独特的生理学。各种肺解剖或病理生理变化都可能危及最佳的法洛四联症循环。接受当代全腔肺动脉连接术的患者的长期生存率是令人满意的。彻底的文献复习结合积累的临床经验，可以使临床医生得出关于法洛四联症与肺相互作用的结论，这也是本次综述的目的。
