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使用可流动的伤口基质治疗下肢血管性溃疡。

Use of a flowable wound matrix to treat lower limb vascular ulcers.

机构信息

Department of Translational Medical Sciences, Vascular Surgery Unit, University of Campania "Luigi Vanvitelli" Medical School, Naples, Italy.

Vascular and Endovascular Surgery Unit, Department of Public Health, University of Naples Federico II, Naples, Italy.

出版信息

J Wound Care. 2021 Nov 2;30(11):896-902. doi: 10.12968/jowc.2021.30.11.896.

Abstract

OBJECTIVES

This study is aimed at assessing the safety and effectiveness of an advanced flowable wound matrix (FWM) in the treatment of hard-to-heal vascular leg ulcers that often involve deep structures, are irregular and/or tunnelled or excavated.

METHODS

Records of patients seen at our Vascular Surgery Unit, at the University of Campania 'Luigi Vanvitelli', for hard-to-heal vascular leg ulcers between January 2018 and January 2020 were retrospectively reviewed. For each wound aetiology, area and complications were recorded and evaluated. Every patient received one or more applications of FWM and was followed up.

RESULTS

A total of 22 patients (18 female/four male), mean age 63±8.5 years, were treated. The initial wound area ranged from 4-58cm. After wound bed preparation, FWM was applied. Treatment was well tolerated and effective-rate of complications was low, graft take was very satisfactory, and no graft loss, rejection or superimposed infections were observed. Healing time was short: 85% of ulcers healed after 12 weeks. Most importantly, there was a decrease in the rate and level of amputations as compared with standard wound care.

CONCLUSIONS

The data presented indicate that FWM is an option for the treatment of hard-to-heal vascular leg ulcers, particularly for those with an irregular cavity.

DECLARATION OF INTEREST

The authors have no conflicts of interest.

摘要

目的

本研究旨在评估一种先进的可流动性创面基质(FWM)在治疗常涉及深部结构、不规则和/或有腔道或隧道的难愈性血管性腿部溃疡中的安全性和有效性。

方法

回顾性分析了 2018 年 1 月至 2020 年 1 月期间在坎帕尼亚大学“路易吉·凡维泰利”血管外科病房就诊的难愈性血管性腿部溃疡患者的病历。记录了每个伤口的病因、面积和并发症,并进行了评估。每位患者接受了一次或多次 FWM 治疗,并进行了随访。

结果

共 22 例患者(18 例女性/4 例男性),平均年龄 63±8.5 岁,接受了治疗。初始伤口面积从 4 到 58cm 不等。在准备好伤口床后,应用 FWM。治疗耐受性良好,并发症发生率低,移植物成活率非常满意,没有发生移植物丢失、排斥或合并感染。愈合时间短:85%的溃疡在 12 周后愈合。最重要的是,与标准伤口护理相比,截肢的发生率和水平都有所下降。

结论

所提供的数据表明,FWM 是治疗难愈性血管性腿部溃疡的一种选择,特别是对于那些有不规则腔的溃疡。

利益声明

作者无利益冲突。

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