Vasular and Endovascular Surgery Unit, Department of Public Health, University of Naples Federico II, Naples, Italy.
Vascular Surgery Unit, Department of Transalational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Int J Low Extrem Wounds. 2022 Sep;21(3):332-336. doi: 10.1177/1534734620945561. Epub 2020 Aug 17.
Nonhealing leg ulcers are a major health problem worldwide with a high economic burden since they require human and material resources. Moreover, nonhealing ulcers are a major nontraumatic cause of lower limb amputations. Dermal substitutes have emerged as an effective therapeutic option for treatment of skin lesions, but data on leg ulcers are scarce. We evaluated safety and efficacy of a porcine-derived dermal substitute in the treatment of chronic vascular leg ulcers. Records of patients with nonhealing ulcers seen at our unit from 2018 to 2019 were retrospectively reviewed. Wound etiology, wound area, and complications were evaluated. Each patient received one application of porcine-derived dermal substitute and was followed-up. Six patients (5 females and 1 male) with a mean age of 61.3 (52-81) years presented with nonhealing leg ulcers. After surgical debridement and wound bed preparation, porcine-derived dermal substitute was applied onto the ulcer. Granulation was satisfactory within 10 days. All wounds healed after an average time of 14 weeks. Graft take was good, and no graft loss, rejection, or associated infection were observed. In conclusion, the data presented indicate that dermal substitutes are safe and effective for treatment of chronic nonhealing vascular leg ulcers.
不愈合的腿部溃疡是一个全球性的主要健康问题，由于需要人力和物力资源，因此具有很高的经济负担。此外，不愈合的溃疡是导致下肢截肢的主要非创伤性原因。皮肤替代物已成为治疗皮肤损伤的有效治疗选择，但关于腿部溃疡的数据很少。我们评估了猪源性皮肤替代物在治疗慢性血管性腿部溃疡中的安全性和疗效。回顾了我们单位 2018 年至 2019 年期间就诊的非愈合性溃疡患者的记录。评估了伤口病因、伤口面积和并发症。每位患者接受一次猪源性皮肤替代物治疗，并进行随访。6 名患者（5 名女性和 1 名男性），平均年龄 61.3 岁（52-81 岁），患有非愈合性腿部溃疡。在进行外科清创和伤口床准备后，将猪源性皮肤替代物应用于溃疡上。10 天内肉芽组织生长良好。所有伤口在平均 14 周后愈合。移植物成活率良好，未观察到移植物丢失、排斥或相关感染。总之，目前的数据表明，皮肤替代物治疗慢性非愈合性血管性腿部溃疡是安全有效的。
