从 L. 中分离得到的一种新生物碱及其抗炎活性。
A new alkaloid from L. and its anti-inflammatory activity.
机构信息
First Affiliated Hospital of Dalian Medical University, Dalian, P.R. China.
School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, P.R. China.
出版信息
Nat Prod Res. 2022 Sep;36(18):4709-4713. doi: 10.1080/14786419.2021.2000984. Epub 2021 Nov 7.
A new alkaloid, identified as ()-2-(4-hydroxyphenyl)-3-(pyridazin-3-yl)-acrylaldehyde, named oleradazine, was isolated from L., and the structure was elucidated using spectroscopic methods, including 1D and 2D NMR spectroscopic and UHPLC-ESI-QTOF/MS methods. In addition, the compound was used to investigate its anti-inflammatory activity in lipopolysaccharide-stimulated macrophages. It was suggested that the oleradazine can significantly inhibit the inflammatory factors, interleukin 1 and nitric oxide in lipopolysaccharide-stimulated RAW 264.7 cells by enzyme-linked immunosorbent assays.
一种新的生物碱，被鉴定为 ()-2-(4- 羟基苯基)-3-(哒嗪-3-基)-丙烯醛，命名为奥来哒嗪，从 中分离得到，其结构通过包括 1D 和 2D NMR 光谱和 UHPLC-ESI-QTOF/MS 方法在内的光谱方法阐明。此外，该化合物被用于研究其在脂多糖刺激的巨噬细胞中的抗炎活性。酶联免疫吸附试验结果表明，奥来哒嗪可显著抑制脂多糖刺激的 RAW 264.7 细胞中的炎症因子白细胞介素 1 和一氧化氮。
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