First Affiliated Hospital of Dalian Medical University, Dalian, P.R. China.
School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, P.R. China.
Nat Prod Res. 2022 Sep;36(18):4709-4713. doi: 10.1080/14786419.2021.2000984. Epub 2021 Nov 7.
A new alkaloid, identified as ()-2-(4-hydroxyphenyl)-3-(pyridazin-3-yl)-acrylaldehyde, named oleradazine, was isolated from L., and the structure was elucidated using spectroscopic methods, including 1D and 2D NMR spectroscopic and UHPLC-ESI-QTOF/MS methods. In addition, the compound was used to investigate its anti-inflammatory activity in lipopolysaccharide-stimulated macrophages. It was suggested that the oleradazine can significantly inhibit the inflammatory factors, interleukin 1 and nitric oxide in lipopolysaccharide-stimulated RAW 264.7 cells by enzyme-linked immunosorbent assays.
一种新的生物碱，被鉴定为 ()-2-(4- 羟基苯基)-3-(哒嗪-3-基)-丙烯醛，命名为奥来哒嗪，从 中分离得到，其结构通过包括 1D 和 2D NMR 光谱和 UHPLC-ESI-QTOF/MS 方法在内的光谱方法阐明。此外，该化合物被用于研究其在脂多糖刺激的巨噬细胞中的抗炎活性。酶联免疫吸附试验结果表明，奥来哒嗪可显著抑制脂多糖刺激的 RAW 264.7 细胞中的炎症因子白细胞介素 1 和一氧化氮。
