Agarwal Mehul, Gupta Manohar Lal, Shadrach Benhur Joel, Bharti Neha
Department of Pulmonary Medicine, All India Institute of Medical Sciences (AIIMS), Jodhpur.
Department of Pulmonary Medicine,Santokba Durlabhji Memorial Hospital, Jaipur.
Acta Biomed. 2021 Oct 6;92(S1):e2021134. doi: 10.23750/abm.v92iS1.10213.
Disseminated Histoplasmosis, a systemic fungal infection caused by Histoplasma capsulatum is predominantly seen in immunocompromised cases. It is usually endemic, although sporadic cases have been reported. Following initial infection to the lungs, it disseminates to various organs by lymphatic and hematogenous routes. Clinical features are non-specific and depend on the extent and severity of organ involvement. A Biopsy is required for diagnosis and timely intervention decreases morbidity and mortality. Our case report describes an atypical association of progressive disseminated Histoplasmosis with bone marrow involvement in an immunocompetent adult from a non-endemic region and alerts the clinicians to a rare yet life-threatening mycosis.
播散性组织胞浆菌病是由荚膜组织胞浆菌引起的一种全身性真菌感染，主要见于免疫功能低下的病例。虽然有散发病例的报道，但它通常呈地方性流行。初次感染肺部后，它通过淋巴和血行途径扩散到各个器官。临床特征不具有特异性，取决于器官受累的程度和严重性。诊断需要进行活检，及时干预可降低发病率和死亡率。我们的病例报告描述了一名来自非流行地区的免疫功能正常成年人中，进行性播散性组织胞浆菌病与骨髓受累的非典型关联，并提醒临床医生注意这种罕见但危及生命的真菌病。
